Trypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive

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dc.creatorBuza, J.
dc.creatorNaessens, Jan
dc.date1999-07
dc.date2013-07-03T05:26:15Z
dc.date2013-07-03T05:26:15Z
dc.date.accessioned2026-06-27T16:48:16Z
dc.descriptionSerum Ig from Trypanosoma congolense-infected cattle were affinity-purified using immobilised trypanosome or non-trypanosome antigens (beta-galactosidase, cytochrome C and ferritin). The bound and unbound IgG and IgM fractions were collected and tested in ELISA for reactivity to each antigen. The results indicated that the presence of reactivity to non-parasite antigens in serum of infected cattle is due to polyreactive IgM antibodies. However, the IgG fraction only bound to trypanosome antigens and was only present in post-infection sera, indicating that it was indiced by the infecting trypanosomes. Since the polyreactive IgM antibodies were also present in pre-infection sera, it is probable that they were natural antibodies that were not induced but only amplified by the trypanosome infection.
dc.identifierhttps://hdl.handle.net/10568/33222
dc.identifier.urihttp://hdl.handle.net/123456789/133617
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceVeterinary Immunology and Immunopathology;69 (1): 1-9
dc.subjecttrypanosoma congolense
dc.subjectantibodies
dc.subjectserum
dc.subjecttrypanosomiasis
dc.subjectcattle
dc.subjectantigens
dc.titleTrypanosome non-specific IgM antibodies detected in serum of Trypanosoma congolense-infected cattle are polyreactive
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)