Protective and inappropriate antibody responses in trypanosome-infected cattle

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dc.creatorWilliams, D.J.L.
dc.creatorTaylor, K.
dc.creatorNewson, J.
dc.creatorNaessens, Jan
dc.creatorAuthié, Edith
dc.date1995
dc.date2010-12-09T11:11:59Z
dc.date2010-12-09T11:11:59Z
dc.date.accessioned2026-06-27T16:45:46Z
dc.descriptionThe trypanosome surface coat is composed almost entirely of a homogeneous array of molecules known as variable surface glycoproteins (VSG). These molecules are highly immunogenic and elicit a strong antibody response in the infected host. Antibodies against the surface-exposed epitopes of a particular VSG mediate the destruction and clearance to trypanosomes expressing that variant. As those parasites are cleared, they are replaced by others expressing antigenically different VSG molecules, which in turn provoke specific antibody responses. Trypanosome infections are therefore characterized by waves of parasitaemia followed by waves of VSG-specific antibody. It is known that trypanotolerant N'Dama cattle infected with Trypanosoma congolense have significantly lower levels of parasitaemia than the more susceptible Boran cattle. It has been suggested that this reflects a more effective VSG-specific antibody response in the N'Damas. We have tested this hypothesis by examining VSG-specific antibody responses in N'Dama and Boran cattle during experimental infection with T. congolense.
dc.identifierhttps://hdl.handle.net/10568/2824
dc.identifier.urihttp://hdl.handle.net/123456789/132472
dc.languageen
dc.publisherInternational Laboratory for Research on Animal Diseases
dc.rightsOpen Access
dc.subjecttrypanosomes (phytomonas)
dc.subjectinfection
dc.subjectimmune response
dc.subjectdisease control
dc.subjectanimal diseases
dc.subjectglossinidae
dc.subjectglossina morsitans
dc.subjectndama cattle
dc.subjectgoats
dc.subjecttrypanosoma congolense
dc.titleProtective and inappropriate antibody responses in trypanosome-infected cattle
dc.typeConference Paper

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Instituto Internacional de Investigaciones Pecuarias (ILRI)