Genomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle

Vista sencilla de ítem
dc.audienceInvestigador
dc.coverageColombia
dc.creatorFernandez Niño, Juan Carlos
dc.creatorPerez Garcia, Juan Esteban
dc.creatorHerrera, N.
dc.creatorMartinez Sarmiento, Rodrigo Alfredo
dc.creatorBejarano Garavito, Diego Hernan
dc.creatorMartinez Rocha, Juan Felipe
dc.date2024-09-24T18:54:32Z
dc.date2024-09-24T18:54:32Z
dc.date2019-05-03
dc.date2019
dc.date.accessioned2026-06-27T04:32:13Z
dc.descriptionInheritance of fertility traits in cattle is complex since they are controlled by multiple loci. Genome-wide association studies are an efficient tool to detect genomic regions that explain the phenotypic variation for a trait of interest. The aim of this study was to identify genomic regions that affect the age at first calving (AFC) and the calving interval (CI) in the Romosinuano (ROMO) and Costeño con Cuernos (CCC) creole cattle breeds and nominate candidate genes that influence these reproductive traits. AFC and CI records were obtained from 4,063 ROMO and 3,922 CCC, and a total of 962 animals were genotyped using the BovineSNP50. Based on the single-step GBLUP methodology, the effects of 54K single nucleotide polymorphisms (SNPs) were grouped within windows of eight adjacent SNPs to explain the genetic variance. Sixty-six SNP windows were significantly associated with AFC (31 regions) and CI (35 regions). Of these regions, 17 were associated with AFC in ROMO, 14 with AFC in CCC, 17 with CI in ROMO and 18 with CI in CCC. From these, nine candidate genes (CACNA1A, CACNA1D, CACTIN, IARS2, PGRMC2, PTGDR, SYT10, UBE4A, RNF17) were identified as possible candidates involved in molecular mechanism that affect physiological mechanisms, such as hormonal regulation, ovarian cyclicity, growth rate, gametogenesis, acceleration of puberty, regulation of immune system, early embryonic development and the pathways to embryo-maternal recognition and maintenance of pregnancy. Furthermore, some genomic regions located in BTA1, BTA5 and BTA14 showed a pleiotropic effect on both AFC and CI. The polymorphisms identified in this study can help determine gene networks involved in the physiology of reproduction in cattle and to explain the inherent genetic variance of traits that measure reproductive performance in cattle. Some of these polymorphisms might be considered for breeding selection strategies to improve complex traits such as AFC and CI in beef and dairy cattle production systems.
dc.descriptionCorporación colombiana de investigación agropecuaria - AGROSAVIA
dc.descriptionInstituto Colombiano Agropecuario - ICA
dc.descriptionMinisterio de Agricultura y Desarrollo Rural - MADR
dc.descriptionGanadería bovina
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.identifierchrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://geneticsmr.com/wp-content/uploads/2024/03/18-2-gmr18258.pdf
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/20.500.12324/40176
dc.identifierhttp://dx.doi.org/10.4238/gmr18258
dc.identifierreponame:Biblioteca Digital Agropecuaria de Colombia
dc.identifierinstname:Corporación colombiana de investigación agropecuaria AGROSAVIA
dc.identifier.urihttp://hdl.handle.net/123456789/30676
dc.languageeng
dc.publisherFundação de Pesquisas Científicas de Ribeirão Preto - FUNPEC-RP
dc.relationGenetics and Molecular Research
dc.relation18
dc.relation2
dc.relation1
dc.relation13
dc.relationAguilar I, Misztal I, Johnson DL, Legarra A, et al. (2010). Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score. J. Dairy. Sci. 93: 743–752.
dc.relationAnimalQTLdb (2017). AnimalQTLdb. http://www.animalgenome.org/cgi-bin/ QTLdb/index. Accessed 7 Dec 2017
dc.relationAlexander W, Aponte T, Chacon JB, Bravo WC, et al. (2011). Serous papillary ovarian cystadenocarcinoma in an 16- year-oldpatient, a case report. Gac. Med. Bol. 34(1): 43-46.
dc.relationBaldwin KL, Dinh EM, Hart BM and Masson PH (2013). CACTIN is an essential nuclear protein in Arabidopsis and may be associated with the eukaryotic spliceosome. FEBS. Lett. 587: 873-879.
dc.relationBarreto TD, Alves JG, Beraldo SD, Bermal R, et al. (2017). Genomic analysis of stayability in Nellore cattle. PLoS One. 12(6): e0179076.
dc.relationBovine HapMap Consortium (2009). Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science. 324: 528–532.
dc.relationBrowning SR and Browning BL (2011). Haplotype phasing: existing methods and new developments. Nat. Rev. Genet. 12(10): 703-14.
dc.relationCao P, Maximov A and Südhof TC (2011). Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell. 145: 300-11.
dc.relationClark N, Pru C, Yee S, Lydon J, et al. (2016). Conditional ablation of progesterone receptor membrane component 2 causes female premature reproductive senescence. Endocrinology. 158(3): 640-651.
dc.relationEnsembl.org (2017). Ensembl.org. https://www.ensembl.org/index.html. Accessed 7 Dic 2017.
dc.relationFarhat A, Philibert P, Sultan C, Poulat F, et al. (2011). Hematopoietic-Prostaglandin D2 synthase through PGD2 production is involved in the adult ovarian physiology. J. Ovarian Res. 4(3): 1-13.
dc.relationGeneCards (2017). GenesCards Human Gene Database. In: Weizmann Inst. Sci. http://www.genecards.org/. Accessed 7 Dic 2017.
dc.relationGraubner FR, Gram A and Kautz E (2017). Uterine responses to early pre-attachment embryos in the domestic dog and comparisons with other domestic animal species. Biol. Reprod. 97(2): 197-216.
dc.relationGrossi DA, Frizzas OG, Paz CCP, Bezerra LAF, et al. (2008). Genetic associations between accumulated productivity, and reproductive and growth traits in Nelore cattle. Livest. Sci. 117: 139-146.
dc.relationHutchison JL, VanRaden PM, Null DJ, Cole JB, et al. (2017). Genomic evaluation of age at first calving. J. Dairy Sci. 100: 6853-6861.
dc.relationJi Y, Han Z, Shao L and Zhao Y (2016). Ultrasound-targeted microbubble destruction of calcium channel subunit α 1D siRNA inhibits breast cancer via G protein-coupled receptor 30. Oncol. Rep. 36: 1886-92.
dc.relationLi F, Shi W, Capurro M and Filmus J (2011). Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating Hedgehog signaling. J. Cell Biol. 192: 691-704.
dc.relationLonergan P (2011). Influence of progesterone on oocyte quality and embryo development in cows. Theriogenology. 76: 1594-1601.
dc.relationMadrid S, Santacreu B, Fontanesi M and Blasco L (2018). A genomic region on chromosome 17 has a major impact on litter size traits in rabbits. In: World Congress on Genetics Applied to Livestock Production. 11: 163.
dc.relationMartínez R, Gallego J, Onofre G, Pérez J, et al. (2009) Evaluación de la variabilidad y potencial genético de poblaciones de bovinos criollos colombianos. AGRI. 44: 57-66.
dc.relationMatukumalli LK, Lawley CT, Schnabel RD, Taylor JF, et al. (2009). Development and characterization of a high density SNP genotyping assay for cattle. PLoS One. 4(4): 1-13.
dc.relationMészáros G, Eaglen S, Waldmann P and Sölkner J (2014). A Genome Wide Association Study for Longevity in Cattle. Open J. Genet. 04(01): 46-55.
dc.relationMisztal I, Aggrey SE and Muir WM (2013). Experiences with a single-step genome evaluation. Poult. Sci. 92: 2530-4.
dc.relationMoosa S, Haagerup A, Gregersen PA, Petersen KK, et al. (2017). Confirmation of CAGSSS syndrome as a distinct entity in a Danish patient with a novel homozygous mutation in IARS2. Am. J. Med. Genet. A. 173: 1102-1108.
dc.relationNicolazzi EL, Biffani S, Biscarini F, Orozco P, et al. (2015). Software solutions for the livestock genomics SNP array revolution. Anim. Genet. 46: 343-353.
dc.relationOrtega MS, Denicol AC and Cole JB (2017). Association of single nucleotide polymorphisms in candidate genes previously related to genetic variation in fertility with phenotypic measurements of reproductive function in Holstein cows. J. Dairy Sci. 100(5): 3725-3734.
dc.relationOssa G, Abuabara Y, Pérez JE and Martínez G (2011). El ganado criollo colombiano Costeño con Cuernos (CCC). Anim. Genet. Resources 48: 101-107
dc.relationOssa G, Hinestroza AD, Rodríguez MS and García SR (2013). Training, development and phenotypic characterization of productive and reproductive characters Romosinuano herd of gene bank Colombia. Corpoica Cienc. Tecnol. Agropecu. 14(2): 231-243.
dc.relationPan J, Goodheart M, Chuma S, Nakatsuji N, et al. (2005) RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 132: 4029-39.
dc.relationPadodara R (2014). Olfactory Sense in Different Animal. Indian J. Vet. Sci. 2(1): 1-14.
dc.relationParker KL, Null DJ and Cole JB (2016). Explorations in genome-wide association studies and network analyses with dairy cattle fertility traits. J. Dairy Sci. 99(8): 6420-6435.
dc.relationPurcell S, Neale B, Todd-Brown K, Thomas L, et al. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81(3): 559-75.
dc.relationRocha JF, Gallego JL, Vásquez RF, Pedraza JA, et al. (2012). Estimation of genetic parameters for age at first calving and calving interval in Blanco Orejinegro (BON) breed cattle populations in Colombia. Rev. Colomb. Cienc. Pecu. 25: 220-228.
dc.relationRolf MM, Taylor JF, Schnabel RD, McKay SD, et al. (2010). Impact of reduced marker set estimation of genomic relationship matrices on genomic selection for feed efficiency in Angus cattle. BMC Genet. 11: 24.
dc.relationSaint-Dizier M, Sandra O, Ployart S, Chebrout M, et al. (2012). Expression of nuclear progesterone receptor and progesterone receptor membrane components 1 and 2 in the oviduct of cyclic and pregnant cows during the postovulation period. Reprod. Biol. Endocrinol. 10: 76.
dc.relationSargolzaei M, Chesnais JP and Schenkel FS (2014). A new approach for efficient genotype imputation using information from relatives. BMC Genomics. 15: 478.
dc.relationSnelling WM, Cushman RA, Keele JW, Maltecca C, et al. (2013). Breeding and genetics symposium: Networks and pathways to guide genomic selection. J. Anim. Sci. 91: 537-552.
dc.relationUniProt (2017). UniProt. http://www.uniprot.org/. Accessed 7 Dic 2017.
dc.relationVanRaden PM (2008). Efficient methods to compute genomic predictions. J. Dairy Sci. 91: 4414-4423.
dc.relationWang H, Misztal I, Aguilar I, Legarra A, et al. (2012). Genome-wide association mapping including phenotypes from relatives without genotypes. Genet. Res. 94: 73-83.
dc.relationWiggans GR, VanRaden PM, Bacheller LR, Tooker ME, et al. (2010). Selection and management of DNA markers for use in genomic evaluation. J. Dairy Sci. 93: 2287-2292.
dc.relationZiminA V, Delcher AL, Florea L, Kelley DR, et al. (2009). A whole-genome assembly of the domestic cow, Bostaurus. Genome Biol. 10: R42.
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceGenetics and Molecular Research; Vol. 18, Núm. 2 (2019): Genetics and Molecular Research (May.);p. 1 - 13.
dc.subjectGenética y mejoramiento animal - L10
dc.subjectGanado bovino
dc.subjectParto
dc.subjectFertilidad
dc.subjectPropiedad biológica
dc.subjectGanadería y especies menores
dc.subjecthttp://aims.fao.org/aos/agrovoc/c_1391
dc.subjecthttp://aims.fao.org/aos/agrovoc/c_5604
dc.subjecthttp://aims.fao.org/aos/agrovoc/c_2862
dc.subjecthttp://aims.fao.org/aos/agrovoc/c_1501
dc.thumbnailhttps://repository.agrosavia.co/bitstreams/c7ec9bd6-1ad2-4678-a0d6-d03542477c29/download
dc.titleGenomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
dc.titleGenomic association study for age at first calving and calving interval in Romosinuano and Costeño con Cuernos cattle
dc.typeArtículo científico

Archivos

Colecciones

Científico