Trapping parasite secretory proteins in baker's yeast

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dc.creatorNene, Vishvanath M.
dc.creatorBishop, Richard P.
dc.date2001-09
dc.date2013-06-11T09:24:29Z
dc.date2013-06-11T09:24:29Z
dc.date.accessioned2026-06-27T16:41:07Z
dc.descriptionBecause the function of signal sequences has been conserved during evolution it has been possible to develop both bioinformatics resources to identify them and techniques to clone genes that encode secretary proteins. The latter entail insertion of heterologous signals upstream of signal peptide deleted reporter genes. We discuss the advantages of using Saccharomyces cerevisiae for signal sequence trap technology. The yeast protein-translocation system appears to be less discriminating than that of higher eukaryotes - for example, a Theileria parva cysteine protease gene containing a recessed, nonclassical signal allows access to the secretary pathway- and yeast technology could have general application in studying elements of parasite protein trafficking.
dc.identifierhttps://hdl.handle.net/10568/29685
dc.identifier.urihttp://hdl.handle.net/123456789/130350
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceTrends in Parasitology;17(9): 407-409
dc.subjectparasites
dc.subjecttrapping
dc.subjectyeast
dc.subjecttheileria parva
dc.subjectproteins
dc.titleTrapping parasite secretory proteins in baker's yeast
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)