Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial

Vista sencilla de ítem
dc.creatorHoang, Quoc Huy
dc.creatorHo, Hung Sy
dc.creatorDo, Huong Thuy
dc.creatorNguyen, Tien Viet
dc.creatorNguyen, Phuong Hong
dc.creatorLe, Minh Tam
dc.date2021-07-01
dc.date2024-05-22T12:11:14Z
dc.date2024-05-22T12:11:14Z
dc.date.accessioned2026-06-27T15:39:51Z
dc.descriptionPurpose: This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods: In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregnancy rate, and ongoing pregnancy rate. Results: No significant differences were observed in the number of oocytes retrieved, mature oocytes and embryos between all groups. Human chorionic gonadotropin (hCG) positive, clinical, and ongoing pregnancy rates were significantly higher in the TTG pretreatment groups than in the control group but no differences were observed between the 4‐ and 6 week groups. Conclusions: Applying TTG in infertile women with POR may ameliorate the outcomes of IVF. The extended application of TTG to 6 weeks did not improve the response to ovarian stimulation regarding the number of retrieved oocytes nor pregnancy outcomes compared to the 4 week pretreatment.
dc.identifierhttps://hdl.handle.net/10568/142883
dc.identifier.urihttp://hdl.handle.net/123456789/111011
dc.languageen
dc.publisherWiley
dc.rightsOpen Access
dc.sourceHoang, Quoc Huy; Ho, Hung Sy; Do, Huong Thuy; Nguyen, Tien Viet; Nguyen, Phuong Hong; and Le, Minh Tam. 2021. Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial. Reproductive Medicine and Biology 20(3): 305-312. https://doi.org/10.1002/rmb2.12383
dc.subjecttestosterone
dc.subjectovaries
dc.subjectdrugs
dc.subjectpregnancy
dc.subjectpoor ovarian response
dc.subjectinfertility
dc.subjectreproductive disorders
dc.subjectfemale infertility
dc.subjectin vitro fertilization
dc.subjectova
dc.subjectreproduction
dc.titleTherapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigación sobre Políticas Alimentarias (IFPRI)