Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues

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dc.creatorKopp, N.
dc.creatorDíaz, D.
dc.creatorAmacker, M.
dc.creatorOdongo, David O.
dc.creatorBeier, K.
dc.creatorNitsch, C.
dc.creatorBishop, Richard P.
dc.creatorDaubenberger, C.A.
dc.date2009-12
dc.date2010-01-12T05:47:34Z
dc.date2010-01-12T05:47:34Z
dc.date.accessioned2026-06-27T16:41:26Z
dc.descriptionThe BM86 antigen, originally identified in Rhipicephalus (Boophilus) microplus, is the basis of the only commercialized anti-tick vaccine. The long-term goal of our study is to improve BM86 based vaccines by induction of high levels of tick gut binding antibodies that are also cross-reactive with a range of BM86 homologues expressed in other important tick species. Here we have used a BD86 derived synthetic peptide, BD86-3, to raise a series of mouse monoclonal antibodies. One of these mAbs, named 12.1, recognized BM86 homologues in immuno-histochemical analyses in four out of five tick species including R. (B.) microplus, Rhipicephalus (Boophilus) decoloratus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus. Our results indicate that broadly cross-reactive tick gut binding antibodies can be induced after immunization with a synthetic peptide derived from the protein BD86.
dc.identifierhttps://hdl.handle.net/10568/381
dc.identifier.urihttp://hdl.handle.net/123456789/130509
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceKopp, N.; Diaz, D.; Amacker, M.; Odongo, D.O.; Beier, K.; Nitsch, C.; Bishop, R.P.; Daubenberger, C.A. 2009. Identification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues Vaccine. v. 28(1). p. 261-269.
dc.titleIdentification of a synthetic peptide inducing cross-reactive antibodies binding to Rhipicephalus (Boophilus) decoloratus, Rhipicephalus (Boophilus) microplus, Hyalomma anatolicum anatolicum and Rhipicephalus appendiculatus BM86 homologues
dc.typeJournal Article

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