Active surveillance for emerging influenza A viruses – Findings from a One Health study in Vietnam’s live bird markets

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dc.creatorVuong N. Bui
dc.creatorOguzie, J.U.
dc.creatorTung D. Dao
dc.creatorAnh N. Bui
dc.creatorSon D. Tran
dc.creatorQuy D. Nguyen
dc.creatorHung Q. Nguyen
dc.creatorTrujillo-Vargas, C.M.
dc.creatorMarushchak, L.V.
dc.creatorThang Nguyen-Tien
dc.creatorShittu, I.
dc.creatorHung Nguyen-Viet
dc.creatorPhuc Duc Pham
dc.creatorHuy C. Nguyen
dc.creatorBrooks, J.S.
dc.creatorGray, G.C.
dc.date2025-12
dc.date2025-10-16T18:19:34Z
dc.date2025-10-16T18:19:34Z
dc.date.accessioned2026-06-27T16:34:21Z
dc.descriptionObjectives: Live bird markets (LBMs) in Asia have often been the source of human infections with avian influenza virus (AIV). Methods: From July 2021 to August 2023, we employed a One Health approach in conducting periodic surveillance for novel influenza A viruses in five LBMs in northern Vietnam. Specimens were studied with egg culture, molecular assays, Sanger sequencing, and next-generation sequencing. Results: We studied a total of 688 human, avian, and bioaerosol specimens. Among these, 118 (17.2%) were found to have molecular evidence of AIVs. Next-generation sequencing of 92 isolates revealed multiple AIV subtypes, including H4N6 (n=1), H5N1 (n=3), H5N8 (n=6), H6N2 (n=3), H6N6 (n=18), and H9N2 (n=61) and mix infections (n=7). Our H5Nx sequences belonged to the Eurasian lineage clade 2.3.4.4b, while our H6N2 sequences were of group III, H6N6 of group II, and H9N2 of the BJ94-lineage clade 4.6.14. Conclusions: The relatively high prevalence of AIV, particularly highly pathogenic H5N1 and H5N8 viruses, along with the subtype diversity, frequent co-infections and notable mutations, highlights the urgent need for continued monitoring and control of AIV in Vietnam’s poultry farms and LBMs.
dc.identifierhttps://hdl.handle.net/10568/177178
dc.identifier.urihttp://hdl.handle.net/123456789/126892
dc.languageen
dc.publisherElsevier
dc.rightsOpen Access
dc.sourceVuong N. Bui, Oguzie, J.U., Tung D. Dao, Anh N. Bui, Son D. Tran, Quy D. Nguyen, Hung Q. Nguyen, Trujillo-Vargas, C.M., Marushchak, L.V., Thang Nguyen-Tien, Shittu, I., Hung Nguyen-Viet, Phuc Duc Pham, Huy C. Nguyen, Brooks, J.S. and Gray, G.C. 2025. Active surveillance for emerging influenza A viruses – Findings from a One Health study in Vietnam’s live bird markets. International Journal of Infectious Diseases 161: 108132.
dc.subjectavian influenza
dc.subjectdisease surveillance
dc.subjectinfluenzavirus
dc.subjectlive bird markets
dc.subjectone health approach
dc.titleActive surveillance for emerging influenza A viruses – Findings from a One Health study in Vietnam’s live bird markets
dc.typeJournal Article

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