Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays

Vista sencilla de ítem
dc.creatorAiyedun, P.O.
dc.creatorSonibare, M.A.
dc.creatorGueye, B.
dc.creatorAlbach, D.C.
dc.creatorHeil, J.
dc.creatorMorlock, G.E.
dc.date2025-01
dc.date2025-05-09T09:55:04Z
dc.date2025-05-09T09:55:04Z
dc.date.accessioned2026-06-27T16:06:36Z
dc.descriptionTrifoliate yam (Dioscorea dumetorum) is traditionally used to treat diabetics in Nigeria. However, almost no information is available on its antidiabetic constituents and their natural variance. Hence, the activity of methanolic tuber extracts of 67 trifoliate yam accessions from the largest collection in Africa was proven by four colorimetric antidiabetic and antioxidant in vitro assays, as diabetes is also linked with oxidative stress. For the first time, selected accessions were also analyzed by planar bioactivity profiling. It has a comparatively higher, more differentiated information content, is more sustainable in terms of material consumption, and enables straightforward compound prioritization and characterization. Up to a dozen individual antioxidant zones were revealed as well as one prominent zone inhibiting α-glucosidase and α-amylase. The latter inhibition zone was tentatively assigned to palmitic, linoleic, oleic, linolenic, oxo-nonanoic fatty acids by direct elution to heated electrospray ionization high-resolution mass spectrometry.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/174510
dc.identifier.urihttp://hdl.handle.net/123456789/122796
dc.languageen
dc.publisherElsevier
dc.rightsOpen Access
dc.sourceAiyedun, P.O., Sonibare, M.A., Gueye, B., Albach, D.C., Heil, J. & Morlock, G.E. (2025). Antidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays. Fitoterapia, 180: 106299, 1-12.
dc.subjectdioscorea
dc.subjectbioactive properties
dc.subjectchromatography
dc.titleAntidiabetic and antioxidant profiling of 67 African trifoliate yam accessions by planar on-surface assays versus in vitro assays
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Agricultura Tropical (IITA)