Characterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex

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dc.creatorMacHugh, Niall D.
dc.creatorMburu, J.K.
dc.creatorHamilton, M.J.
dc.creatorDavis, W.C.
dc.date1998-02
dc.date2013-06-11T09:25:11Z
dc.date2013-06-11T09:25:11Z
dc.date.accessioned2026-06-27T16:32:34Z
dc.descriptionThe characterisation of a monoclonal antibody (mAb), designated MM1A, which reacts with an antigen molecule on the surface of bovine alfa beta and gama delta TcR+ T cells is described. The mAb immunoprecipitated a series of polypeptides of 21 kDa, 22 kDa, 36 kDa and 44 kDa which is consistent with it recognising the TcR/CD3 complex. COS cells, transfected with a cDNA encoding the bovine CD3e chain, reacted with mAb MM1A indicating that the epitope recognised is on the chain of the complex and confirming the mAb recognised bovine CD3.
dc.identifierhttps://hdl.handle.net/10568/29861
dc.identifier.urihttp://hdl.handle.net/123456789/125949
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceVeterinary Immunology and Immunopathology;61(1): 25-35
dc.subjectbovinae
dc.subjectmonoclonal antibodies
dc.subjectgenetic transformation
dc.subjectimmunology
dc.titleCharacterisation of a monoclonal antibody recognising the CD3 epsilon chain of the bovine T cell receptor complex
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)