Challenge of Theileria parva (Boleni) immunised cattle with selected East African Theileria stocks

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dc.creatorHove, T.
dc.creatorMusisi, F.L.
dc.creatorKanhai, G.K.
dc.creatorLatif, A.
dc.creatorMasaka, S.
dc.creatorMunatswa, F.C.
dc.creatorPegram, R.G.
dc.creatorKamwendo, S.P.
dc.creatorQuiroga, J.C.
dc.creatorMwangondwe, R.
dc.creatorDolan, T.T.
dc.date1995-12
dc.date2013-06-11T09:24:47Z
dc.date2013-06-11T09:24:47Z
dc.date.accessioned2026-06-27T17:04:44Z
dc.descriptionTheileria parva (Boleni) stock from Zimbabwe was used to immunise 24 susceptible Friesian calves by infection and treatment with oxytetracycline. Twenty-eight days after immunisation the animals in groups of 6 plus 2 susceptible controls were subjected to challenge: 3 groups with heterologous stocks and one group with the immunising stock. Theileria parva (Boleni) gave good protection against homologous challenge, the T. parva (Muguga, Kenya) and buffalo-derived T. parva (Serengeti transformed, Tanzania) parasite stocks. It did not protect against the T. parva (Kasoba, Malawi) stock and 3 out of 6 immunised cattle died and athe remaining 3 had to be treated with parvaquone. In a second experiment, the 6 T. parva (Boleni) immunised animals which had received homologous challenge, together with the 2 controls which had recovered without treatment from T. parva (Boleni) infection, were challenged with the T. parva (Kasoba) stock. Four out of 6 of the immunised animals resisted the challenge with mild to moderate reactions. The other 2 animals had severe reactions and one died. The 2 control animals which recovered from T. parva (Boleni) infection resisted the T. parva (Kasoba) challenge and both had mild reactions. It is suggested that oxytetracycline used in the first experiment may have interfered with the expression of the full protective capacity against the virulent T. parva (Kasoba) stock. Further studies on the use of the T. parva (Boleni) stock without oxytetracycline treatment could identify a more broadly immunising effect and a more economical vaccination method.
dc.identifierhttps://hdl.handle.net/10568/29762
dc.identifier.urihttp://hdl.handle.net/123456789/141564
dc.languageen
dc.publisherSpringer
dc.rightsLimited Access
dc.sourceTropical Animal Health and Production;27(2): 202-210
dc.subjecttheileria parva
dc.subjectimmunization
dc.subjectdisease control
dc.subjectmetastigmata
dc.subjectanimal diseases
dc.subjectcattle
dc.titleChallenge of Theileria parva (Boleni) immunised cattle with selected East African Theileria stocks
dc.typeJournal Article

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