Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract

dc.creator	Mahan, S.M.
dc.creator	Sileghem, M.R.
dc.creator	Smith, G.
dc.creator	Byrom, B.
dc.date	1998
dc.date	2014-10-31T06:22:01Z
dc.date	2014-10-31T06:22:01Z
dc.date.accessioned	2026-06-27T16:33:55Z
dc.description	Immune mechanisms against Cowdria ruminantium infection in livestock hosts are being investigated. This knowledge will be important for identification of protective antigens of C. ruminantium which will have application in the Development of vaccines against heartwater. T-cell Con-A supernatants inhibited the growth of C. ruminantium in-vitro. This effect was neither C. ruminantium strain or bovine endothelial cell type specific. As a follow up to these studies the cytokines responsible for this inhibition were investigated. Antibodies against bovine interferon (IFN) and tissue necrosis factor (TNF) were added to the infected cultures containing the T cell Con-A supernatants. Antibodies to IFN alone were able to block the inhibitory effect of these T cell supernatants. This data demonstrates the possible regulatory role of T cell in control of C. ruminantium infection.
dc.identifier	https://hdl.handle.net/10568/51046
dc.identifier.uri	http://hdl.handle.net/123456789/126678
dc.language	en
dc.publisher	ARC
dc.rights	Limited Access
dc.subject	cowdria ruminantium
dc.subject	growth
dc.subject	disease control
dc.subject	livestock
dc.subject	vaccines
dc.subject	antibodies
dc.title	Role of interferon gamma in control of Cowdria ruminantium growth in-vitro. Abstract
dc.type	Conference Paper

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