A novel coronavirus and a broad range of viruses in Kenyan cave bats

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dc.creatorKamau, J.
dc.creatorErgunay, K.
dc.creatorWebala, P.W.
dc.creatorJusti, S.A.
dc.creatorBourke, B.P.
dc.creatorKamau, M.W.
dc.creatorHassell, James M.
dc.creatorChege, M.N.
dc.creatorMwaura, D.K.
dc.creatorSimiyu, C.
dc.creatorKibiwot, S.
dc.creatorOnyuok, S.
dc.creatorCaicedo-Quiroga, L.
dc.creatorLi, T.
dc.creatorZimmerman, D.M.
dc.creatorLinton, Y.M.
dc.date2022-12-17
dc.date2022-12-27T07:07:11Z
dc.date2022-12-27T07:07:11Z
dc.date.accessioned2026-06-27T16:34:40Z
dc.descriptionBackground and Methods: To investigate virus diversity in hot zones of probable pathogen spillover, 54 oral-fecal swabs were processed from five bat species collected from three cave systems in Kenya, using metagenome sequencing. Results: Viruses belonging to the Astroviridae, Circoviridae, Coronaviridae, Dicistroviridae, Herpesviridae and Retroviridae were detected, with unclassified viruses. Retroviral sequences were prevalent; 74.1% of all samples were positive, with distinct correlations between virus, site and host bat species. Detected retroviruses comprised Myotis myotis, Myotis ricketti, Myotis daubentonii and Galidia endogenous retroviruses, murine leukemia virus-related virus and Rhinolophus ferrumequinum retrovirus (RFRV). A near-complete genome of a local RFRV strain with identical genome organization and 2.8% nucleotide divergence from the prototype isolate was characterized. Bat coronavirus sequences were detected with a prevalence of 24.1%, where analyses on the ORF1ab region revealed a novel alphacoronavirus lineage. Astrovirus sequences were detected in 25.9%of all samples, with considerable diversity. In 9.2% of the samples, other viruses including Actinidia yellowing virus 2, bat betaherpesvirus, Bole tick virus 4, Cyclovirus and Rhopalosiphum padi virus were identified. Conclusions: Further monitoring of bats across Kenya is essential to facilitate early recognition of possibly emergent zoonotic viruses.
dc.identifierhttps://hdl.handle.net/10568/126312
dc.identifier.urihttp://hdl.handle.net/123456789/127058
dc.languageen
dc.publisherMDPI
dc.rightsOpen Access
dc.sourceKamau, J., Ergunay, K., Webala, P.W., Justi, S.A., Bourke, B.P., Kamau, M.W., Hassell, J., Chege, M.N., Mwaura, D.K., Simiyu, C., Kibiwot, S., Onyuok, S., Caicedo-Quiroga, L., Li, T., Zimmerman, D.M. and Linton, Y.M. 2022. A novel coronavirus and a broad range of viruses in Kenyan cave bats. Viruses 14(12): 2820.
dc.subjectcoronavirinae
dc.subjectchiroptera
dc.subjectviruses
dc.subjectbiodiversity
dc.subjecthealth
dc.subjectvirology
dc.subjectinfectious diseases
dc.titleA novel coronavirus and a broad range of viruses in Kenyan cave bats
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)