HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle.

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dc.contributorMarielle Moura Baena, UFLA; Polyana Cristiane Tizioto, UFSCAR; Sarah Laguna Conceição Meirelles, UFLA; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
dc.creatorBAENA, M. M.
dc.creatorTIZIOTO, P. C.
dc.creatorMEIRELLES, S. L. C.
dc.creatorREGITANO, L. C. de A.
dc.date2019-02-20T00:36:33Z
dc.date2019-02-20T00:36:33Z
dc.date2019-02-19
dc.date2018
dc.date2019-02-20T00:36:33Z
dc.date.accessioned2026-07-07T05:27:20Z
dc.descriptionThe purpose of this study was to access and characterize single nucleotide polymorphisms (SNP) located within the HSF1 and HSPA6 candidate genes for adaptability in Angus breed raised in subtropical climate. Samples of DNA from 20 animals representing extreme phenotypes for adaptability traits were obtained. Sequence variations in the candidate genes were described by sequencing target regions. We identified 12 SNP located in the HSF1 gene. Moreover, four of the six SNP found in the HSPA6 gene cause amino acid substitutions in protein-coding regions. We also identified a representative SNP (called tag SNP) in a region of the HSF1 gene with high linkage disequilibrium (r2 = 0.87) that may represent 11 SNP located in this gene. Minor allele frequency observed for the SNP ranged from 0.10 to 0.50 and 0.02 to 0.21 for the HSF1 and the HSPA6 genes, respectively. Overall, almost all SNP analyzed showed significant deviation from the Hardy-Weinberg Equilibrium and half of the loci had heterozygosity greater than 0.50. The data suggest that there is sequence variability in these genes that could be exploited by breeding programs. There is genetic variation in HSF1 and HSPA6 genes in this populations of Angus breed, which is fundamental to obtain response to selection.
dc.identifierRevista Brasileira de Zootecnia, v.47,e20160390, p. 2-7, 2018.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1106259
dc.identifierhttps://doi.org/10.1590/rbz4720160390
dc.identifier.urihttp://hdl.handle.net/123456789/491746
dc.languageeng
dc.rightsopenAccess
dc.subjectMolecular makers
dc.subjectRaça Angus
dc.subjectGado de Corte
dc.subjectBovino
dc.subjectAngus
dc.subjectThermoregulation
dc.subjectBeef cattle
dc.titleHSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle.
dc.typeArtigo de periódico

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