Characterization of a novel microdeletion polymorphism on BTA5 in cattle.

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dc.contributorUSDA
dc.contributorR.W. LI, USDA-ARS
dc.contributorTAD S. SONSTEGARD, USDA
dc.contributorLAKSHMI MATUKUMALLI, GEORGE MASON UNIVERSITY
dc.contributorMARCOS VINICIUS GUALBERTO B SILVA, CNPGL
dc.contributorCURTIS VAN TASSELL, USDA.
dc.creatorLIU, G. E.
dc.creatorLI, R. W.
dc.creatorSONSTEGARD, T. S.
dc.creatorMATUKUMALLI, L. K.
dc.creatorSILVA, M. V. G. B.
dc.creatorVAN TASSELL, C. P.
dc.date2024-05-14T16:52:52Z
dc.date2024-05-14T16:52:52Z
dc.date2009-03-06
dc.date2008
dc.date.accessioned2026-07-07T03:55:43Z
dc.descriptionWe present a detailed breakpoint mapping and population frequency analysis of a 214-kb microdeletion that removes multiple olfactory receptor genes. Using progressive rounds of PCR assays, we mapped the upstream and downstream breakpoints of this microdeletion event to 1 and 12 kb genomic regions, respectively. We developed PCR-based genotyping assays, characterized a dairy cattle panel of 96 samples and found that the frequency of the deletion allele was over 51%. Our results indicated that this microdeletion is an ancient event occurring in one of the earlier founders, and that it has been stably inherited across generations in the North American dairy cattle population.
dc.identifierAnimal Genetics, v. 39, n. 6, p. 655-658, 2008.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/596819
dc.identifierhttps://doi.org/10.1111/j.1365-2052.2008.01769.x
dc.identifier.urihttp://hdl.handle.net/123456789/447718
dc.languageeng
dc.rightsopenAccess
dc.subjectBreakpoint
dc.subjectCattle genome
dc.subjectDeletion
dc.subjectPopulation frequency
dc.subjectStructural variants
dc.titleCharacterization of a novel microdeletion polymorphism on BTA5 in cattle.
dc.typeArtigo de periódico

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