Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers

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dc.creatorPrado, Elizabeth L.
dc.creatorArnold, Charles D.
dc.creatorWessells, K. Ryan
dc.creatorStewart, Christine P.
dc.creatorAbbeddou, Souheila
dc.creatorAdu-Afarwuah, Seth
dc.creatorArnold, Benjamin F.
dc.creatorBecquey, Elodie
dc.creatorHuybregts, Lieven
dc.date2021-11-01
dc.date2024-05-22T12:10:20Z
dc.date2024-05-22T12:10:20Z
dc.date.accessioned2026-06-27T15:04:11Z
dc.descriptionBackground Small-quantity (SQ) lipid-based nutrient supplements (LNSs) provide many nutrients needed for brain development. Objectives We aimed to generate pooled estimates of the effect of SQ-LNSs on developmental outcomes (language, social-emotional, motor, and executive function), and to identify study-level and individual-level modifiers of these effects. Methods We conducted a 2-stage meta-analysis of individual participant data from 14 intervention against control group comparisons in 13 randomized trials of SQ-LNSs provided to children age 6–24 mo (total n = 30,024). Results In 11–13 intervention against control group comparisons (n = 23,588–24,561), SQ-LNSs increased mean language (mean difference: 0.07 SD; 95% CI: 0.04, 0.10 SD), social-emotional (0.08; 0.05, 0.11 SD), and motor scores (0.08; 95% CI: 0.05, 0.11 SD) and reduced the prevalence of children in the lowest decile of these scores by 16% (prevalence ratio: 0.84; 95% CI: 0.76, 0.92), 19% (0.81; 95% CI: 0.74, 0.89), and 16% (0.84; 95% CI: 0.76, 0.92), respectively. SQ-LNSs also increased the prevalence of children walking without support at 12 mo by 9% (1.09; 95% CI: 1.05, 1.14). Effects of SQ-LNSs on language, social-emotional, and motor outcomes were larger among study populations with a higher stunting burden (≥35%) (mean difference: 0.11–0.13 SD; 8–9 comparisons). At the individual level, greater effects of SQ-LNSs were found on language among children who were acutely malnourished (mean difference: 0.31) at baseline; on language (0.12), motor (0.11), and executive function (0.06) among children in households with lower socioeconomic status; and on motor development among later-born children (0.11), children of older mothers (0.10), and children of mothers with lower education (0.11). Conclusions Child SQ-LNSs can be expected to result in modest developmental gains, which would be analogous to 1–1.5 IQ points on an IQ test, particularly in populations with a high child stunting burden. Certain groups of children who experience higher-risk environments have greater potential to benefit from SQ-LNSs in developmental outcomes.
dc.identifierhttps://hdl.handle.net/10568/142331
dc.identifier.urihttp://hdl.handle.net/123456789/93618
dc.languageen
dc.publisherAmerican Society for Nutrition
dc.relationhttps://doi.org/10.1186/s12889-017-4146-6
dc.relationhttps://doi.org/10.1371/journal.pmed.1002892
dc.rightsOpen Access
dc.sourcePrado, Elizabeth L.; Arnold, Charles D.; Wessells, K. Ryan; Stewart, Christine P.; Abbeddou, Souheila; Adu-Afarwuah, Seth; Arnold, Benjamin F.; Becquey, Elodie; Huybregts, Lieven; et al. 2021. Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers. American Journal of Clinical Nutrition 114(Supplement 1): 43S-67S. https://doi.org/10.1093/ajcn/nqab277
dc.subjectmaternal and child health
dc.subjectlipids
dc.subjectfood supplements
dc.subjectchild nutrition
dc.subjectchild development
dc.subjectstunting
dc.subjectnutrients
dc.subjectmalnutrition
dc.subjectsupplements
dc.subjectnutrition
dc.subjecttrace elements
dc.subjectfeeding
dc.titleSmall-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers
dc.typeJournal Article

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Instituto Internacional de Investigación sobre Políticas Alimentarias (IFPRI)