Malaria infection confounds inflammation-adjusted micronutrient biomarker concentrations in children and women in Malawi: a secondary analysis of the 2015/2016 Malawi micronutrient survey

Vista sencilla de ítem
dc.creatorSandalinas, Fanny
dc.creatorJoy, Edward J. M.
dc.creatorHopkins, Heidi
dc.creatorLikoswe, Blessings H.
dc.creatorBlake, Tineka
dc.creatorLuo, Hanqi
dc.creatorYoung, Melissa F.
dc.creatorBottomley, Christian
dc.creatorSuchdev, Parminder S.
dc.creatorFilteau, Suzanne
dc.date2025-05-14
dc.date2025-07-15T19:23:32Z
dc.date2025-07-15T19:23:32Z
dc.date.accessioned2026-06-27T15:44:47Z
dc.descriptionInflammation and infections such as malaria affect concentrations of many micronutrient biomarkers and hence estimates of nutritional status. We aimed to assess the relationship between malaria infection and micronutrient biomarker concentrations in pre-school children (PSC), school-age children (SAC) and women of reproductive age (WRA) in Malawi and examine the potential role of malarial immunity on the relationship between malaria and micronutrient biomarkers. Data from the 2015/2016 Malawi micronutrient survey were used. The associations between current or recent malaria infection, detected by rapid diagnostic test and concentration of serum ferritin, soluble transferrin receptor (sTfR), zinc, serum folate, red blood cell folate and vitamin B12 were estimated using multivariable linear regression. Factors related to malarial immunity including age, altitude and presence of hemoglobinopathies were examined as effect modifiers. Serum ferritin, sTfR and zinc were adjusted for inflammation using the BRINDA method. Malaria infection was associated with 68 % (95 % CI 51, 86), 28 % (18, 40) and 34 % (13, 45) greater inflammation-adjusted ferritin in PSC, SAC and WRA, respectively (P < 0·001 for each). In PSC, the positive association was stronger in younger children, high altitude and children who were not carriers of the sickle cell trait. In PSC and SAC, sTfR was elevated (+ 25 % (16, 29) and + 15 % (9, 22) respectively, P < 0·001). Serum folate and erythrocyte folate were elevated in WRA with malaria (+ 18 % (3, 35) and + 11 % (1, 23), P = 0·01 and P = 0·003 respectively). Malaria affects the interpretation of micronutrient biomarker concentrations, and examining factors related to malarial immunity may be informative.
dc.identifierhttps://hdl.handle.net/10568/175647
dc.identifier.urihttp://hdl.handle.net/123456789/113438
dc.languageen
dc.publisherCambridge University Press
dc.rightsOpen Access
dc.sourceSandalinas, Fanny; Joy, Edward J. M.; Hopkins, Heidi; Likoswe, Blessings H.; Blake, Tineka; Luo, Hanqi; et al. 2025. Malaria infection confounds inflammation-adjusted micronutrient biomarker concentrations in children and women in Malawi: a secondary analysis of the 2015/2016 Malawi micronutrient survey. British Journal of Nutrition 133(9): 1276 - 1286. https://doi.org/10.1017/S0007114525000820
dc.subjectbiomarkers
dc.subjectchildren
dc.subjectmalaria
dc.subjectnutrition
dc.subjecttrace elements
dc.subjectwomen
dc.titleMalaria infection confounds inflammation-adjusted micronutrient biomarker concentrations in children and women in Malawi: a secondary analysis of the 2015/2016 Malawi micronutrient survey
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigación sobre Políticas Alimentarias (IFPRI)