Immune depression in trypanosome-infected mice. I. Depressed T lymphocyte responses

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dc.creatorPearson, T.W.
dc.creatorRoelants, G.E.
dc.creatorLundin, L.B.
dc.creatorMayor-Withey, K.S.
dc.date1978-10
dc.date2013-05-06T07:00:51Z
dc.date2013-05-06T07:00:51Z
dc.date.accessioned2026-06-27T16:44:32Z
dc.descriptionUsing a wide range of experimental conditions, several kinds of T lymphocyte responses in spleen cell populations from trypanosome‐infected mice were studied. Lymphocyte stimulation after culture with the mitogen concanavalin A or with histoincompatible cells differing at H‐2 or minor lymphocyte‐stimulating loci was reduced or abolished in spleen cells from infected mice when compared with responses of spleen cells from uninfected controls. In addition, cytotoxic lymphocytes were not generated in mixed lymphocyte cultures which contained spleen cells from infected animals. Allogeneic skin grafting experiments performed with normal and infected mice showed that a decreased T lymphocyte response also occurs in vivo. The depressed immune responses were not simply due to low numbers of T lymphocytes in spleens of infected animals, but reflected a generalized immune depression which was not antigen‐specific.
dc.identifierhttps://hdl.handle.net/10568/28548
dc.identifier.urihttp://hdl.handle.net/123456789/131931
dc.languageen
dc.publisherWiley
dc.rightsLimited Access
dc.sourceEuropean Journal of Immunology;8: 723-727
dc.subjectimmune response
dc.subjecttrypanosoma
dc.subjectlymphocytes
dc.subjectmice
dc.subjectanimal diseases
dc.subjectdisease control
dc.titleImmune depression in trypanosome-infected mice. I. Depressed T lymphocyte responses
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)