In vivo depletion of T-cell subsets in cattle
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International Laboratory for Research on Animal Diseases
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Techniques for in vivo depletion of lymphocytes using monoclonal antibodies have been well documented for murine systems. This model has played an important role in analysing the involvement of various lymphocyte subsets in several immune mechanisms. In mice 600 ug of Ab are generally injected intraperitoneally once a week. In order to study bovine specific immune mechanisms we have attempted to adapt this technology to cattle.
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cattle, lymphocytes, monoclonal antibodies, disease control, immune response, vaccines, immunization