Molecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.

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dc.contributorLUCIO FABIO CALDAS FERRAZ, CBMEG/Unicamp; FERNANDA SOARDI, CBMEG/Unicamp; PAULA REGINA KUSER FALCAO, CNPTIA; GORAN NESHICH, CNPTIA; MARICILDA PALANDI DE MELLO, CBMEG/Unicamp.
dc.creatorFERRAZ, L. F. C.
dc.creatorSOARDI, F.
dc.creatorFALCÃO, P.
dc.creatorNESHICH, G.
dc.creatorMELLO, M. P. de
dc.date2022-05-17T18:13:32Z
dc.date2022-05-17T18:13:32Z
dc.date2006-08-17
dc.date2006
dc.date.accessioned2026-07-07T04:16:59Z
dc.descriptionShort abstract: We describe the mutation Pro222GIn in HSD3B2 gene on a patient with congenital adrenal hyperplasia. Molecular modeling of 3B-HSD2 mutant allowed us to identify critical role of residue Pro222 on the folding pattern and catalytic activity of the enzyme. The proposed models correlate with the experimental data previously reported.
dc.descriptionISMB, X-MEETING 2006. Poster D-12.
dc.formatNão paginado.
dc.identifierIn: ANNUAL INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS FOR MOLECULAR BIOLOGY, 14.; ANNUAL AB3C CONFERENCE, 2., 2006, Fortaleza. Conference Program... Fortaleza: ISCB, 2006.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/9296
dc.identifier.urihttp://hdl.handle.net/123456789/456359
dc.languageeng
dc.rightsopenAccess
dc.subjectMutação gênica
dc.subjectHiperplasia adrenal congenital
dc.subjectModelagem molecular
dc.subjectBiologia molecular
dc.subjectMutation
dc.subjectHyperplasia
dc.subjectMolecular Biology
dc.titleMolecular homologous modeling of 3B-HSD2 mutant enzyme: structure-function aspects of Pro222GLN mutation correlates with the experimental data from a patient with congenital adrenal hyperplasia.
dc.typeResumo em anais e proceedings

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