Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

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dc.creatorDomínguez Salas, Paula
dc.creatorMoore, S.E.
dc.creatorBaker, M.S.
dc.creatorBergen, A.W.
dc.creatorCox, S.E.
dc.creatorDyer, R.A.
dc.creatorFulford, A.J.
dc.creatorGuan, Y.
dc.creatorLaritsky, E.
dc.creatorSilver, M.J.
dc.creatorSwan, G.E.
dc.creatorZeisel, S.H.
dc.creatorInnis, S.M.
dc.creatorWaterland, R.A.
dc.creatorPrentice, A.M.
dc.creatorHennig, B.J.
dc.date2014-04-29
dc.date2014-12-17T07:18:05Z
dc.date2014-12-17T07:18:05Z
dc.date.accessioned2026-06-27T17:17:21Z
dc.descriptionIn experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.
dc.identifierhttps://hdl.handle.net/10568/52239
dc.identifier.urihttp://hdl.handle.net/123456789/147833
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceDominguez-Salas, P., Moore, S.E., Baker, M.S., Bergen, A.W., Cox, S.E., Dyer, R.A., Fulford, A.J., Guan, Y., Laritsky, E., Silver, M.J., Swan, G.E., Zeisel, S.H., Innis, S.M., Waterland, R.A., Prentice, A.M. and Hennig, B.J. 2014. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nature Communications 5: 3746.
dc.subjectgenetics
dc.titleMaternal nutrition at conception modulates DNA methylation of human metastable epialleles
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)