Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.

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dc.creatorTaracha, E.L.N.
dc.creatorGoddeeris, B.M.
dc.creatorTeale, A.J.
dc.creatorKemp, Stephen J.
dc.creatorMorrison, W. Ivan
dc.date1995-11-15
dc.date2024-09-11T09:26:01Z
dc.date2024-09-11T09:26:01Z
dc.date.accessioned2026-06-27T17:17:39Z
dc.descriptionThe parasite strain specificity of CTL responses to Theileria parva varies among cattle immunized with the same parasite stock. We have investigated the influence of class I MHC on the strain specificity of CTL responses to T. parva in 19 cattle of defined class I phenotype immunized with either of two T. parva populations, in which protection to subsequent reciprocal challenge correlated with CTL strain specificity. In the majority of animals the response was restricted by the products of one MHC haplotype and there was a consistent bias to some haplotypes in preference to others. In 10 of 13 cattle expressing the molecularly defined MHC specificities A10 and KN104 on one haplotype, the CTL response was restricted entirely by this haplotype, thus allowing a precise analysis of the MHC restriction specificities. The MHC restriction specificity and the parasite population used for immunization both influenced the strain specificity of the response. By examining responses in identical twins immunized with different parasites or in animals before and after challenge with heterologous parasites, animals that mounted a strain-specific response to primary infection were shown to be capable of responding to Ags shared by the two parasite populations. These findings indicate that the strain specificity of CTL responses to T. parva is not determined primarily by immune response genes that define the inherent capacity to respond, but rather is a consequence of the response in individual animals being biased toward a limited number of immunodominant peptide-MHC determinants.
dc.identifierhttps://hdl.handle.net/10568/152125
dc.identifier.urihttp://hdl.handle.net/123456789/147981
dc.languageen
dc.publisherThe American Association of Immunologists
dc.rightsOpen Access
dc.sourceTaracha, E. L., Goddeeris, B. M., Teale, A. J., Kemp, S. J., & Morrison, W. I. (1995). Parasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance. The Journal of Immunology, 155(10), 4854–4860. https://doi.org/10.4049/jimmunol.155.10.4854
dc.subjectcattle
dc.subjectanalysis
dc.subjecttheileria parva
dc.subjectgenes
dc.subjectinfection
dc.subjectparasites
dc.subjectpopulation
dc.subjectimmunization
dc.subjectanimals
dc.subjectimmune response
dc.subjectproducts
dc.subjectprotection
dc.subjectbovine
dc.subjectcapacity
dc.subjecthaplotypes
dc.subjectparasite
dc.titleParasite strain specificity of bovine cytotoxic T cell responses to Theileria parva is determined primarily by immunodominance.
dc.typeJournal Article

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