Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva

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dc.creatorTaracha, E.L.N.
dc.creatorGoddeeris, Bruno M.
dc.creatorMorzaria, S.P.
dc.creatorMorrison, W. Ivan
dc.date1995
dc.date2013-05-06T07:01:20Z
dc.date2013-05-06T07:01:20Z
dc.date.accessioned2026-06-27T17:20:15Z
dc.descriptionThe relationship of strain specificity of class I major histocompatibility complex-restricted parasite-specific cytotoxic T lymphocytes (CTL) responses and cross-protection was investigated in an effort to verify the role of CTL in protection. The parasite strain specificity of the CTL responses generated in 23 cattle immunized with either of 2 immunologically distinct parasite populations was examined, and the susceptibility of individual cattle to challenge with the heterologous parasite population was determined. The frequency of stock-specific or cross-reactive CTL precursor cells (CTLp) in individual animals was measured by a limiting-dilution microassay. A proportion of animals immunized with either parasite exhibited cross-reactive. CTLp, whereas CTLp detected in the remaining animals were specific for the homologous parasite. On challenge with the heterologous stock, those animals with cross-reactive CTLp were solidly protected while those with strain-specific CTLp showed moderate to severe reactions, although many of them recovered. The finding of a close association between strain specificity of the CTL response and protection against challenge provides strong evidence that CTL are important in mediating immunity.
dc.identifierhttps://hdl.handle.net/10568/28751
dc.identifier.urihttp://hdl.handle.net/123456789/149276
dc.languageen
dc.rightsLimited Access
dc.sourceTaracha EL, Goddeeris BM, Morzaria SP, Morrison WI. 1995. Parasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva. Infect Immun 63: 1258-1262. https://doi.org/10.1128/iai.63.4.1258-1262.1995
dc.subjectparasites
dc.subjectcattle
dc.subjecttheileria parva
dc.subjectlymphocytes
dc.subjectanimal diseases
dc.titleParasite strain specificity of precursor cytotoxic T cells in individual animals correlates with cross-protection in cattle challenged with Theileria parva
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)