Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes

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dc.creatorGraham, S.P.
dc.creatorPelle, Roger
dc.creatorHonda, Y.
dc.creatorMwangi, David Miano
dc.creatorTonukari, N.J.
dc.creatorYamage, M.
dc.creatorGlew, E.J.
dc.creatorVilliers, Etienne P. de
dc.date2006-02-28
dc.date2010-05-07T11:05:01Z
dc.date2010-05-07T11:05:01Z
dc.date.accessioned2026-06-27T17:01:27Z
dc.descriptionEast Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites.
dc.identifierhttps://hdl.handle.net/10568/1406
dc.identifier.urihttp://hdl.handle.net/123456789/139984
dc.languageen
dc.publisherNational Academy of Sciences
dc.rightsOpen Access
dc.sourceGraham S., et al. 2006. Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 103(9):3286-3291.
dc.subjectanimal diseases
dc.subjectdisease control
dc.titleTheileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)