Investigation of the spread bovine tuberculosis in Southern Brazil by Whole-genome sequencing.
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Mycobacterium bovis is the causal agent of bovine tuberculosis, one of the most important diseases currently facing the cattle industry worldwide. Tracing the source of M. bovis infections that result from movement of livestock is an important tool to understand the epidemiology of bovine tuberculosis (bTB) and defining control/eradication strategies. Whole genome sequencing (WGS) provides a higher resolution than other established typing methods and greatly improves the definition of the regional localization of M. bovis types. Cultures of M. bovis were isolated from 58 bovine granulomatous tissue using conventional methods (Stonebrink medium) from eight dairy farms of the State of Rio Grande do Sul, Southern Brazil. The isolates were sequenced using both llumina technologies NextSeq 500 System and HiSeqX System.
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Whole genome sequencing, Bovine, Mycobacterium bovis BCG, Cattle