Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam

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dc.creatorYoung, Melissa F.
dc.creatorNguyen, Phuong Hong
dc.creatorTran, Lan Mai
dc.creatorKhuong, Long Quynh
dc.creatorMartorell, Reynaldo
dc.creatorRamakrishnan, Usha
dc.date2023-05
dc.date2024-03-14T12:08:47Z
dc.date2024-03-14T12:08:47Z
dc.date.accessioned2026-06-27T15:18:42Z
dc.descriptionBackground: The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. Objective: We examined associations between maternal preconception Hb concentrations and anemia with: a) birth outcomes (weight, length, preterm, gestational age, small-for-gestational-age); b) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; c) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6-7y (Wechsler Intelligence Scale for Children). Methods: We used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited and offspring were prospectively followed from birth (n=1599) through 6-7y (n=1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 11g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child and household levels. Results: At preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01,0.12), 6 mo (0.08; 95% CI: 0.03,0.13), 12 mo (0.10; 95% CI: 0.04-0.15) and 24 mo (0.07; 95% CI: 0.02,0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6mo (0.89; 95% CI: 0.81-0.98), 12 mo (0.81; 95% CI: 0.74-0.89) and 24 mo (0.87; 95% CI: 0.79-0.95). Maternal preconception anemia was negatively associated with cognition (-1.64; 95% CI: -3.09, -0.19) and language development (-1.61; 95% CI: -3.20, -0.03) at 24mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6-7y. Conclusion: Maternal preconception Hb was associated with child Hb across the first 1000 days of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6-7y in this cohort from Vietnam.
dc.identifierhttps://hdl.handle.net/10568/139977
dc.identifier.urihttp://hdl.handle.net/123456789/100768
dc.languageen
dc.publisherElsevier
dc.rightsOpen Access
dc.sourceYoung, M. F., Nguyen, P., Tran, L. M., Khuong, L. Q., Martorell, R., & Ramakrishnan, U. (2023). Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam. In The Journal of Nutrition (Vol. 153, Issue 5, pp. 1597–1606). Elsevier BV. https://doi.org/10.1016/j.tjnut.2023.03.015
dc.subjectmaternal and child health
dc.subjectanaemia
dc.subjectchild health
dc.subjectinfant development
dc.subjecthaemoglobin
dc.subjectwomen
dc.subjectdata analysis
dc.subjectdata
dc.subjectchild development
dc.subjectmaternal nutrition
dc.titleLong term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam
dc.typeJournal Article

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