Acute toxicity, risk assessment, and exposure of Nile tilapia larvae after stress to sub-lethal concentrations of oxytetracycline.

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dc.contributorNATALIA AKEMI TAKESHITA; BRUNA MILKE CHISTE; CLAUDIO MARTIN JONSSON, CNPMA; CRISTIANO CAMPOS MATTIOLI; HAMILTON HISANO, CNPMA.
dc.creatorTAKESHITA, N. A.
dc.creatorCHISTE, B. M.
dc.creatorJONSSON, C. M.
dc.creatorMATTIOLI, C. C.
dc.creatorHISANO, H.
dc.date2025-01-20T12:46:59Z
dc.date2025-01-20T12:46:59Z
dc.date2025-01-20
dc.date2024
dc.date.accessioned2026-07-07T05:10:20Z
dc.descriptionAbstract: The present study evaluated the median lethal concentration (LC50-96h), risk assessment, biometrics of weight and length, and mortality of Nile tilapia Oreochromis niloticus larvae exposed to oxytetracycline (OTC). A total of 126 fish (mean weight: 32.25±3.74 mg; mean length: 13.01±0.64 mm; 7 larvae per aquarium) were utilized for the LC50-96h assessment. These fish were randomly distributed across 21 aquaria (1 L each) containing graded concentrations of OTC: 0.0, 2.01, 2.44, 3.31, 3.65, and 4.59 mg/L. Additionally, an acute stress test involving 180 fish (mean weight: 33.9±0.73 mg; mean length: 13.06±0.72 mm; 10 larvae per aquarium) was conducted, wherein the fish were subjected to air stress for 5 minutes before being randomly allocated to 18 aquaria (1 L each) and exposed to sub-lethal concentrations of OTC: 0.0, 0.03, 0.82, 1.65, 2.47, and 3.30 mg/L. Water quality parameters (temperature, pH, dissolved oxygen, conductivity, total ammonia, and total hardness) were monitored daily throughout the experiment. The LC50-96h for OTC in Nile tilapia larvae was estimated at 3.45 mg/L. Larval weight and length significantly decreased in both tests with increasing OTC exposure. Dissolved oxygen levels exhibited significant changes over 96 hours. The post-stress test revealed significant differences (P <0.05) in pH, temperature, and dissolved oxygen. Notably, pre-exposure to air stress exacerbated the toxic effects of sub-lethal OTC levels. Risk quotient analysis indicated a high potential risk for Nile tilapia larvae exposed to therapeutic OTC concentrations.
dc.identifierInternational Aquatic Research, (2024). https://doi.org/10.22034/iar.2024.2008792.1707 [Online first: 14 October 2024]
dc.identifier2008-6970
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1171732
dc.identifier.urihttp://hdl.handle.net/123456789/482842
dc.languageeng
dc.rightsopenAccess
dc.subjectTilápia Nilótica
dc.subjectOreochromis Niloticus
dc.subjectLarva
dc.subjectAntibiótico
dc.subjectToxidez
dc.subjectFreshwater fish
dc.subjectFish larvae
dc.subjectWater pollution
dc.subjectAntibiotics
dc.subjectAntibiotic residues
dc.subjectRisk assessment
dc.subjectToxicity
dc.subjectAquaculture
dc.subjectbiosafety
dc.titleAcute toxicity, risk assessment, and exposure of Nile tilapia larvae after stress to sub-lethal concentrations of oxytetracycline.
dc.typeArtigo de periódico

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