Simulated gastrointestinal digestion/Caco-2 cell model to predict bioaccessibility and intestinal permeability of p-coumaric acid and p-coumaroyl derivatives in peanut.

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dc.contributorADNA PRADO MASSARIOLI, ESALQ; ALAN GIOVANINI DE OLIVEIRA SARTORI, ESALQ; FERNANDA FRANCETTO JULIANO, ESALQ; JOSÉ EDUARDO PEDROSO GOMES DO AMARAL, ESALQ; ROSEANE CAVALCANTI DOS SANTOS, CNPA; LIZIANE MARIA DE LIMA, CNPA; SEVERINO MATIAS DE ALENCAR, ESALQ.
dc.creatorMASSARIOLI, A. P.
dc.creatorSARTORI, A. G. de O.
dc.creatorJULIANO, F. F.
dc.creatorAMARAL, J. E. P. G. do
dc.creatorSANTOS, R. C. dos
dc.creatorLIMA, L. M. de
dc.creatorALENCAR, S. M. de
dc.date2023-03-28T16:50:47Z
dc.date2023-03-28T16:50:47Z
dc.date2023-03-28
dc.date2023
dc.date.accessioned2026-06-30T23:16:39Z
dc.descriptionData concerning physiological recovery of whole peanut major phenolics throughout the gastrointestinal tract are scarce. In our study, the bioaccessibility and intestinal permeability of peanuts major phenolics were predicted by simulated digestion followed by Caco-2 cells monolayer model. Phenolics identification and quantification were performed by HPLC-ESI-QTOF-MS and HPLC-PDA, respectively. As results, p-coumaroyl conjugates with tartaric, sinapic and ferulic acids, and p-coumaric acid were the major phenolics found in the non-digested extract and in the digested and transported fractions. The in vitro bioaccessibility and Caco-2 cell transport of pcoumaric acid was 370% and 127%, respectively, while it was much lower for p-coumaroyl derivatives (7-100% and 14-31%, respectively). Nonetheless, the peroxyl scavenging activity remained unaltered, likely, at least artly, due to synergies between some phenolics, which concentration proportions changed throughout the experiment. Hence, there is indication that whole peanut is a source of bioavailable antioxidant phenolics.
dc.identifierFood Chemistry, v. 400, 134036, p. 1-8, 2023.
dc.identifier2590-1575
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1152824
dc.identifier.urihttp://hdl.handle.net/123456789/378042
dc.languageeng
dc.rightsopenAccess
dc.subjectAmendoim
dc.subjectProteína Vegetal
dc.subjectNutrição Humana
dc.subjectÓleo Vegetal
dc.subjectPhenolic compounds
dc.subjectPeanuts
dc.subjectArid zones
dc.titleSimulated gastrointestinal digestion/Caco-2 cell model to predict bioaccessibility and intestinal permeability of p-coumaric acid and p-coumaroyl derivatives in peanut.
dc.typeArtigo de periódico

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