Foot-and-Mouth Disease Quarterly report

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This Q2 FMD report is prepared by the World Reference Laboratory for Foot-and-Mouth Disease (WRLFMD), Pirbright and the European Commission for the Control of Food-and-Mouth Disease (EuFMD). During this period, the WRLFMD has reported test results for samples received from Ethiopia, Jordan, Kenya, Namibia, Nigeria, Malawi and Uganda. There have also been new sequence submissions from Libya (from IZSLER, Italy) and Türkiye (from Şap Enstitüsü, Türkiye). Sequences of the viruses recovered from the Ugandan and Ethiopian samples provide important insights about the prevailing FMD situation in East Africa. As highlighted in previous studies, two different serotype O topotypes O/EA-2 and O/EA-3 are present in Uganda and Ethiopia, respectively, supporting the idea that there are two discrete FMDV ecosystems in East Africa. In this report, we also describe the detection of a new clade within the SAT1/VII topotype. These sequences from Uganda are >10% different to their closest genetic relatives (viruses collected from the region during the 1970s), representing another example of the unexpected re-emergence of a SAT lineage virus from Africa, like the patterns observed for the SAT2/V and SAT2/VIX topotypes described in previous reports.

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