Synthesis of the tetracyclic nucleus of epi-Sarcophytin, and evaluation of its activity.

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dc.contributorMARIA LUCIA FERREIRA, CNPF.
dc.creatorFERREIRA, M. L.
dc.creatorMODA, T.
dc.creatorBROCKSOM, U.
dc.creatorBROCKSOM, T. J.
dc.date2025-06-17T19:47:35Z
dc.date2025-06-17T19:47:35Z
dc.date2004-10-27
dc.date2003
dc.date.accessioned2026-07-07T03:33:42Z
dc.descriptionWe have been investigating the synthesis of (+)-Sarcophytin o (3) and correlated compounds, and also studying their possible phytotoxic activity. For the synthesis of the tetracyclic nucleus of the C-1-epimer of (+)-3, we chose the halocyclization reaction (NBS in THF/H>20) of Diels-Alder (o) cycloadduct (+)-1, producing compound (+)-2 in 81% yield. Thus (+)-2 can now be obtained in six steps from the cheap chiron (R)-(+)-pulegone in 24% overall yield.
dc.identifierIn: BRAZILIAN MEETING ON ORGANIC SYNTHESIS, 10., 2003, São Pedro. [Abstracts...]. Campinas: Unicamp, 2003.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/309712
dc.identifier.urihttp://hdl.handle.net/123456789/437161
dc.languageeng
dc.rightsopenAccess
dc.subjectSarcophytin
dc.subjectDiels-Alder
dc.subjectPhytotoxic
dc.titleSynthesis of the tetracyclic nucleus of epi-Sarcophytin, and evaluation of its activity.
dc.typeResumo em anais e proceedings

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