Exploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?

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dc.creatorMwangi, David Miano
dc.creatorGraham, S.P.
dc.creatorPelle, Roger
dc.creatorHonda, Y.
dc.creatorTonukari, N.J.
dc.creatorYamage, I.M.
dc.creatorGlew, E.J.
dc.creatorVilliers, Etienne P. de
dc.creatorShah, Tushaar
dc.creatorBishop, Richard P.
dc.creatorAbuya, E.
dc.creatorAwino, Elias
dc.creatorGachanja, J.
dc.creatorLuyai, A.E.
dc.creatorMbwika, F.
dc.creatorMuthiani, A.M.
dc.creatorNdegwa, D.M.
dc.creatorNjahira, Moses N.
dc.creatorNyanjui, J.K.
dc.creatorOnono, F.O.
dc.creatorOsaso, J.
dc.creatorSaya, Rosemary M.
dc.creatorWildmann, C.
dc.creatorFraser, C.M.
dc.creatorMaudlin, I.
dc.creatorGardner, M.J.
dc.creatorMorzaria, S.P.
dc.creatorLoosmore, S.
dc.creatorGilbert, S.C.
dc.creatorAudonnet, J.C.
dc.creatorBruggen, P. van der
dc.creatorNene, Vishvanath M.
dc.creatorTaracha, E.L.N.
dc.date2006
dc.date2014-10-31T06:09:19Z
dc.date2014-10-31T06:09:19Z
dc.date.accessioned2026-06-27T17:00:54Z
dc.descriptionTheileria parva, a tick-borne api-complexan protozoan parasite, causes East Coast fever (ECF) in cattle. Control of the disease by improved vaccination is believed to provide a sustainable solution. Class I MHC-restricted CD8+ cytotoxic T lymphocytes (CTL) directed at schizontinfected cells constitute the effector immune mechanism against ECF in cattle recovering from a single or multiple infection(s). Schizont antigens recognised by CTL are therefore prime vaccine candidates. We describe a rational approach used to identify 8 CTL target antigens as vaccine candidates. The genes encoding the target antigens have been engineered in plasmid DNA and viral vectors for evaluating their immunogenicity and efficacy in cattle. In a preliminary trial, five of the candidate vaccines demonstrated the capacity to induce CTL responses that correlated with survival and reduced disease severity following a lethal parasite challenge.
dc.identifierhttps://hdl.handle.net/10568/50513
dc.identifier.urihttp://hdl.handle.net/123456789/139717
dc.languageen
dc.publisherTanzania Society for Animal Production
dc.rightsLimited Access
dc.subjectcattle
dc.subjecteast coast fever
dc.subjectgenomes
dc.subjectimmunity
dc.subjectdisease resistance
dc.subjecthosts
dc.subjecttheileria parva
dc.subjectvaccines
dc.subjectparasites
dc.subjectantigens
dc.subjecttechnology
dc.subjectimmunogenetics
dc.titleExploiting host immunity and parasite genomics to develop a robust sub-unit vaccine against East Coast fever in cattle - Where are we?
dc.typeConference Paper

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Instituto Internacional de Investigaciones Pecuarias (ILRI)