Sero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda

Vista sencilla de ítem
dc.creatorBugeza, James
dc.creatorRoesel, Kristina
dc.creatorMugizi, Denis
dc.creatorAlinaitwe, Lordrick
dc.creatorKivali, Velma
dc.creatorKankya, C.
dc.creatorMoriyon, I.
dc.creatorCook, Elizabeth A.J.
dc.date2024-03-18
dc.date2024-03-21T08:46:37Z
dc.date2024-03-21T08:46:37Z
dc.date.accessioned2026-06-27T17:13:09Z
dc.description<b>Introduction</b> Brucellosis is a febrile zoonosis occurring among high-risk groups such as livestock keepers and abattoir workers and is a public health priority in Uganda. The technical complexities of bacteriological and molecular methods make serological approaches the cornerstone of diagnosis of human brucellosis in resource limited settings. Therefore, proper application and interpretation of serological tests is central to achieve a correct diagnosis. <b>Materials and methods</b> We conducted a cross-sectional study to estimate the seroprevalence and factors associated with anti-<i>Brucella</i> antibodies among slaughterhouse workers processing ruminants and pigs in three regions of the country with serial testing using a combination of the Rose Bengal Test (RBT) and the BrucellaCapt test. An authorized clinician collected 543 blood samples from consenting abattoir workers as well as attribute medical and social demographic data. Univariable and multivariable logistic regression were used to determine factors associated with anti-<i>Brucella</i> sero-positivity. <b>Results and discussion</b> The sero-prevalence among ruminant slaughterhouse workers ranged from 7.3% (95% CI: 4.8–10.7) using BrucellaCapt to 9.0% (95% CI: 6.3–12.7) using RBT. Slaughterhouse workers from the Eastern regions (AOR = 9.84, 95%CI 2.27–69.2, p = 0.006) and those who graze animals for alternative income (AOR = 2.36, 95% CI: 1.91–6.63, p = 0.040) were at a higher risk of exposure to <i>Brucella</i>. Similarly, those who wore Personal Protective Equipment (AOR = 4.83, 95%CI:1.63–18.0, p = 0.009) and those who slaughter cattle (AOR = 2.12, 95%CI: 1.25–6.0, p = 0.006) were at a higher risk of exposure to <i>Brucella</i>. Those who slaughter small ruminants (AOR = 1.54, 95%CI: 1.32–4.01, p = 0.048) were also at a higher risk of exposure to <i>Brucella</i>. <b>Conclusions and recommendations</b> Our study demonstrates the combined practical application of the RBT and BrucellaCapt in the diagnosis of human brucellosis in endemic settings. Both pharmaceutical (e.g., routine testing and timely therapeutic intervention), and non-pharmaceutical (e.g., higher index of suspicion of brucellosis when investigating fevers of unknown origin and observation of strict abattoir hygiene) countermeasures should be considered for control of the disease in high-risk groups.
dc.identifierhttps://hdl.handle.net/10568/140533
dc.identifier.urihttp://hdl.handle.net/123456789/145758
dc.languageen
dc.publisherPublic Library of Science
dc.rightsOpen Access
dc.sourceBugeza, J.K., Roesel, K., Mugizi, D.R., Alinaitwe, L., Kivali, V., Kankya, C., Moriyon, I. and Cook, E.A.J. 2024. Sero-prevalence and risk factors associated with occurrence of anti-<i>Brucella</i> antibodies among slaughterhouse workers in Uganda. <i>PLOS Neglected Tropical Diseases</i> 18(3): e0012046.
dc.subjectbrucellosis
dc.subjectzoonoses
dc.titleSero-prevalence and risk factors associated with occurrence of anti-Brucella antibodies among slaughterhouse workers in Uganda
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)