A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology

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dc.creatorGraham, S.P.
dc.creatorHonda, Y.
dc.creatorPelle, Roger
dc.creatorMwangi, David Miano
dc.creatorGlew, E.J.
dc.creatorVilliers, Etienne P. de
dc.creatorShah, Tushaar
dc.creatorBishop, Richard P.
dc.creatorBruggen, P. van der
dc.creatorNene, Vishvanath M.
dc.creatorTaracha, E.L.N.
dc.date2007
dc.date2010-05-06T09:07:49Z
dc.date2010-05-06T09:07:49Z
dc.date.accessioned2026-06-27T17:19:05Z
dc.descriptionImmunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypothesized that identification of CTL target schizont antigens will aid the development of a sub-unit vaccine. We exploited the availability of the complete genome sequence data and bioinformatics tools to identify genes encoding secreted or membrane anchored proteins that may be processed and presented by the MHC class I molecules of infected cells to CTL.
dc.identifierhttps://hdl.handle.net/10568/1394
dc.identifier.urihttp://hdl.handle.net/123456789/148691
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceGraham, S.P.; Honda, Y.; Pelle, R. et al. 2007. A novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology. Immunome Research 3:2.
dc.subjectanimal diseases
dc.subjectdisease control
dc.titleA novel strategy for the identification of antigens that are recognised by bovine MHC class I restricted cytotoxic T cells in a protozoan infection using reverse vaccinology
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)