State of research on the interactions between food additives, the gut microbiome and the host
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A scientific literature review was conducted with a focus on food safety to critically assess the current research on the impact of selected food additives on, and their interactions with the gut microbiome, as well as the resulting implications for host health. The review's main goals were to:> Gather and assess the quantity, quality, and reliability of scientific information,> Identify research limitations, knowledge gaps, and related needs,> Explore the applicability of microbiome data in food safety chemical risk assessments.This review concludes on recommendations to guide and improve microbiome science in risk assessment. Through this work, the Agrifood Systems and Food Safety Division contributes to the FAO’s role of improving food safety by encouraging high-quality research to produce robust data, promoting effective scientific communication, and investigating how knowledge regarding gut microbiome-food additive interactions could potentially support the modernization of food safety chemical risk assessments.