Mining of the endophytic microbiome for novel biosynthetic genes and antifungal metabolites.

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dc.contributorVictor J Carrion, Netherlands Institute of Ecology (NIOO-KNAW), Netherlands
dc.contributorJuan PÉREZ-JARAMILLO, Netherlands Institute of Ecology (NIOO-KNAW), Netherlands
dc.contributorViviane Cordovez, Neethrlands Institutee of Ecology (NIOO-KNAW), Netherlands
dc.contributorMattias de Hollander, Netherlands Institute of Ecology (NIOOKNAW), Netherlands
dc.contributorMattias de Hollander, Wageningen University, Netherlands
dc.contributorLucas W. Mendes, USP
dc.contributorRODRIGO MENDES, CNPMA
dc.contributorMarnix H Medema, Wageningen University, Netherlands
dc.contributorJos M. Raaijmakers, Netherlands Institute of Ecology (NIOO-KNAW), Netherlands.
dc.creatorCARRION, V. J.
dc.creatorPÉREZ-JARAMILLO, J.
dc.creatorCORDOVEZ, V.
dc.creatorHOLLANDER, M. de
dc.creatorTRACANNA, V.
dc.creatorMENDES, L. W.
dc.creatorMENDES, R.
dc.creatorMEDEMA, M. H.
dc.creatorRAAIJMAKERS, J. M.
dc.date2019-01-11T00:11:11Z
dc.date2019-01-11T00:11:11Z
dc.date2019-01-10
dc.date2018
dc.date2019-01-11T00:11:11Z
dc.date.accessioned2026-07-07T05:06:28Z
dc.descriptionEndophytic microbes have been proposed to contribute to a range of plant support functions, including nutrient acquisition and disease protection. To date, the molecular mechanisms underlying disease protection in the endosphere have only been studied for individual culturable organisms. Here, we conducted a systematic microbiome-wide perspective on the taxonomic diversity and functional potential of the endophytic microbiome of plants grown in an agricultural soil that is naturally suppressive to damping-off disease caused by the fungal root pathogen Rhizoctonia solani. Metagenomic analyses showed an enrichment of Burkholderiaceae, Chitinophagaceae and Xanthomonadaceae in the endosphere of plants grown in disease-suppressive soil challenged with the fungal root pathogen. Binning of the metagenomic sequences allowed de novo assembly of 25 high quality genomes of different endophytic bacterial genera. Subsequent trait-based analyses revealed numerous biosynthetic gene clusters (BGCs) overrepresented in the endophytic bacterial families of plants under fungal pathogen attack, including BGCs involved in signal transduction and antimicrobial activities, in particular nonribosomal peptides and polyketides. Network analyses further indicated that the traits enriched in the endophytic microbiome are multifactorial involving several novel BGCs encoding metabolites with yet unknown activities.
dc.identifierIn: PLANT MICROBIOME SYMPOSIUM, 2., 2018, Amsterdam. [Abstracts...] Amsterdam: Netherlands Institute of Ecology (NIOO-KNAW), 2018.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1103500
dc.identifier.urihttp://hdl.handle.net/123456789/480560
dc.languagepor
dc.rightsopenAccess
dc.subjectMicrobiome
dc.subjectAntifungal agents
dc.subjectMetagenomics
dc.titleMining of the endophytic microbiome for novel biosynthetic genes and antifungal metabolites.
dc.typeResumo em anais e proceedings

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