Protective immune mechanisms against Theileria parva: Evolution of vaccine development strategies

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dc.creatorMcKeever, Declan J.
dc.creatorTaracha, E.L.N.
dc.creatorMorrison, W. Ivan
dc.creatorMusoke, A.J.
dc.creatorMorzaria, S.P.
dc.date1999-07
dc.date2013-07-03T05:26:04Z
dc.date2013-07-03T05:26:04Z
dc.date.accessioned2026-06-27T16:31:26Z
dc.descriptionTheileria parva is an intracellular sporozoan parasite that infects and transforms bovine lymphocytes, causing a severe lymphoproliferative disease known as East Coast fever in eastern, central and southern Africa. In this article, Declan McKeever and colleagues summarize the current understanding of immune mechanisms provoked by the parasite with regard to their role in both pathogenesis and protection. In particular, the influence of genomic polymorphism in parasite and host on the development of immunity is discussed, along with the evolution of current vaccine development strategies as a result of immunological research on the disease.
dc.identifierhttps://hdl.handle.net/10568/33104
dc.identifier.urihttp://hdl.handle.net/123456789/125323
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceParasitology Today;15(7): 263-267
dc.subjecttheileria parva
dc.subjectvaccines
dc.subjecttickborne diseases
dc.subjectimmune response
dc.subjecteast coast fever
dc.subjectimmunological diseases
dc.subjectparasitology
dc.titleProtective immune mechanisms against Theileria parva: Evolution of vaccine development strategies
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)