Metabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.

Vista sencilla de ítem
dc.contributorCAIO BEZERRA DE CASTRO, Universidade Federal de São Carlos. Departamento de Química; LICIA DOS REIS LUZ, Universidade Federal do Ceará. Departamento de Química Analítica e Físico-Química.; JHONYSON ARRUDA CARVALHO GUEDES, CNPAT; DIOGO DENARDI PORTO, CPATSA; MARIA FRANCILENE SOUZA SILVA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM); GISELE SILVESTRE DA SILVA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; DÁVILA DE SOUZA ZAMPIERI, Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica.; ClLAUDIA DO Ó PESSOA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM).; GUILHERME JULIAO ZOCOLO, CNPAT.
dc.creatorCASTRO, C. B. DE
dc.creatorLUZ, L. DOS R.
dc.creatorGUEDES, J. A. C.
dc.creatorPORTO, D. D.
dc.creatorSILVA, M. F. S.
dc.creatorSILVA, G. S. DA
dc.creatorRIBEIRO, P. R. V.
dc.creatorCANUTO, K. M.
dc.creatorBRITO, E. S. de
dc.creatorZAMPIERI, D. DE S.
dc.creatorPESSOA, C. do Ó.
dc.creatorZOCOLO, G. J.
dc.date2023-01-13T10:01:20Z
dc.date2023-01-13T10:01:20Z
dc.date2020-01-24
dc.date2020
dc.date.accessioned2026-07-07T05:57:40Z
dc.descriptionMyracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract.
dc.identifierJournal of the Brazilian Chemical Society, v. 31, n. p. 775-787, 2020.
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1119316
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20190242
dc.identifier.urihttp://hdl.handle.net/123456789/503418
dc.languageeng
dc.rightsopenAccess
dc.subjectUPLC-MS/MS
dc.subjectQuimiometria
dc.subjectAtividade citotóxica
dc.subjectAroeira do sertão
dc.subjectBioma Caatinga
dc.subjectMyracrodruon Urundeuva
dc.subjectAroeira
dc.subjectCaatinga
dc.subjectEspécie Nativa
dc.subjectVegetação Nativa
dc.subjectChemometrics
dc.subjectCytotoxicity
dc.titleMetabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.
dc.typeArtigo de periódico

Archivos

Colecciones

Embrapa Semi-Árido (CPATSA)