Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds

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dc.creatorRekik, Emna
dc.creatorAhbara, Abulgasim
dc.creatorAbate, Zelalem
dc.creatorGoshme, Shenkute
dc.creatorGetachew, Tesfaye
dc.creatorHaile, Aynalem
dc.creatorRischkowsky, Barbara
dc.creatorMwacharo, Joram
dc.date2022-06-01
dc.date2023-01-04T18:18:01Z
dc.date2023-01-04T18:18:01Z
dc.date.accessioned2026-06-27T14:24:21Z
dc.descriptionIn recent times, community-based breeding programs (CBBPs) have been advocated as the best strategy for genetic improvement of local breeds in smallholder farms in developing countries. Since 2009, CBBPs have been implemented for Ethiopian Bonga and Menz sheep to improve growth rates resulting in significant genetic gains in 6-month weights. With the hypothesis that selection could be impacting their genomes, we systematically screened for possible genome changes in the two breeds by analyzing 600K BeadChip genotype data of 151 individuals (with the highest breeding values for 6-month weights) from CBBP f locks against 98 individuals from non-CBBP f locks. We observed no differences in genetic diversity and demographic dynamics between CBBP and non-CBBP f locks. Selection signature analysis employing ROH, logistic regression genome-wide association study, FST, XP-EHH and iHS revealed 5 (Bonga) and 11 (Menz) overlapping regions under selection, that co-localized with QTLs for production (body size/weight, growth, milk yield), meat/milk quality, and health/parasite resistance, suggesting that the decade- long selection has likely started to impact their genomes. However, genome- wide genetic differentiation between the CBBP and non-CBBP f locks is not yet clearly evident.
dc.formatapplication/pdf
dc.identifierhttps://hdl.handle.net/10568/126564
dc.identifier.urihttp://hdl.handle.net/123456789/78742
dc.languageen
dc.publisherWiley
dc.rightsOpen Access
dc.sourceEmna Rekik, Abulgasim Ahbara, Zelalem Abate, Shenkute Goshme, Tesfaye Getachew, Aynalem Haile, Barbara Rischkowsky, Joram Mwacharo. (1/6/2022). Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds. Animal Genetics, 53 (3), pp. 447-451.
dc.subjectsheep
dc.subjectgenetic improvement
dc.subjectbreeds
dc.subjectovis aries
dc.subjectselection signatures
dc.subjectgoal 1 no poverty
dc.subjectsheep
dc.subjectdiversity
dc.subjectgenome-wide
dc.subjectmenz
dc.subjectbonga
dc.subjectpoverty reduction, livelihoods and jobs
dc.titleGenomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds
dc.typeJournal Article

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