Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever

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dc.creatorWarimwe, G.M.
dc.creatorGesharisha, J.
dc.creatorCarr, B.V.
dc.creatorOtieno, S.
dc.creatorOtingah, K.
dc.creatorWright, D.
dc.creatorCharleston, B.
dc.creatorOkoth, Edward A.
dc.creatorElena, L.G.
dc.creatorLorenzo, G.
dc.creatorAyman, E.B.
dc.creatorAlharbi, N.K.
dc.creatorAl-Dubaib, M.A.
dc.creatorBrun, A.
dc.creatorGilbert, S.C.
dc.creatorNene, Vishvanath M.
dc.creatorHill, A.V.S.
dc.date2016-02-05
dc.date2016-02-15T20:08:25Z
dc.date2016-02-15T20:08:25Z
dc.date.accessioned2026-06-27T16:59:29Z
dc.descriptionRift Valley Fever virus (RVFV) causes recurrent outbreaks of acute life-threatening human and livestock illness in Africa and the Arabian Peninsula. No licensed vaccines are currently available for humans and those widely used in livestock have major safety concerns. A ‘One Health’ vaccine development approach, in which the same vaccine is co-developed for multiple susceptible species, is an attractive strategy for RVFV. Here, we utilized a replication-deficient chimpanzee adenovirus vaccine platform with an established human and livestock safety profile, ChAdOx1, to develop a vaccine for use against RVFV in both livestock and humans. We show that single-dose immunization with ChAdOx1-GnGc vaccine, encoding RVFV envelope glycoproteins, elicits high-titre RVFV-neutralizing antibody and provides solid protection against RVFV challenge in the most susceptible natural target species of the virus-sheep, goats and cattle. In addition we demonstrate induction of RVFV-neutralizing antibody by ChAdOx1-GnGc vaccination in dromedary camels, further illustrating the potency of replication-deficient chimpanzee adenovirus vaccine platforms. Thus, ChAdOx1-GnGc warrants evaluation in human clinical trials and could potentially address the unmet human and livestock vaccine needs.
dc.identifierhttps://hdl.handle.net/10568/71057
dc.identifier.urihttp://hdl.handle.net/123456789/139011
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceWarimwe, G.M., Gesharisha, J., Carr, B.V., Otieno, S., Otingah, K., Wright, D., Charleston, B., Okoth, E., Elena, L.-G., Lorenzo, G., Ayman, E.B., Alharbi, N.K., Al-dubaib, M.A., Brun, A., Gilbert, S.C., Nene, V. and Hill, A.V.S. 2016. Chimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever. Scientific Reports 6: 20617.
dc.subjectanimal diseases
dc.subjectvaccines
dc.subjectzoonoses
dc.titleChimpanzee adenovirus vaccine provides multispecies protection against Rift Valley fever
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)