Phytotoxic and antifungal compounds for agriculture are interestingly produced by the endophytic fungus Fusarium sp. (Ascomycota) isolated from Piper sp. (Piperaceae).

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dc.contributorDEBORA LUIZA C. BARRETO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; CHARLES L. CANTRELL, UNITED STATES DEPARTMENT OF AGRICULTURE; SEONG J. KIM, UNITED STATES DEPARTMENT OF AGRICULTURE; CAMILA R. DE CARVALHO, UNIVERSIDADE FEDERAL DE MINAS GERAIS; SONIA CLAUDIA DO NASCIMENTO DE QUEIROZ, CNPMA; JOANNA BAJSA-HIRSCHEL, UNITED STATES DEPARTMENT OF AGRICULTURE; PRABIN TAMANG, UNITED STATES DEPARTMENT OF AGRICULTURE; STEPHEN OSCAR DUKE, UNIVERSITY OF MISSISSIPPI; LUIZ HENRIQUE ROSA, UNIVERSIDADE FEDERAL DE MINAS GERAIS.
dc.creatorBARRETO, D. L. C.
dc.creatorCANTRELL, C. L.
dc.creatorKIM, S. J.
dc.creatorCARVALHO, C. R. de
dc.creatorQUEIROZ, S. C. do N. de
dc.creatorBAJSA-HIRSCHEL, J.
dc.creatorTAMANG, P.
dc.creatorDUKE, S. O.
dc.creatorROSA, L. H.
dc.date2025-11-27T14:48:54Z
dc.date2025-11-27T14:48:54Z
dc.date2025-11-27
dc.date2025
dc.date.accessioned2026-07-07T05:10:49Z
dc.descriptionAbstract: Our study focused on the phytotoxic and antifungal activities of metabolites isolated from Fusarium sp., an endophyte associated with the medicinal plant Piper sp. Chromatographic separations of the Fusarium sp. crude extract led to the isolation of three analogous compounds: anhydrofusarubin (1), 5,10-dihydroxy-1,7-dimethoxy-3- methyl-1H-benzo[g]isochromene-6,9-dione (2), and javanicin (3). The structures of the isolated compounds were determined by high-resolution mass spectrometry (HRMS) analysis and direct comparison of 13C NMR data with that reported in the literature. The isolated compounds were evaluated for phytotoxic activity against Lactuca sativa and Agrostis stolonifera. All compounds exhibited strong phytotoxic activity on both plant species, completely inhibiting seed germination at a concentration of 1 mg mL1 . Additionally, the isolated compounds were evaluated against Lemna paucicostata, achieving a 50% growth inhibition (IC50) at concentration of 64, 28, and 31 μM for compounds 1, 2, and 3, respectively. The antifungal activity of these compounds was evaluated using a bioautography assay targeting the agricultural pathogen Colletotrichum fragariae. Among them, compound 2 demonstrated significant antifungal activity. Our results showed that tropical medicinal plants harbor an interesting endophyte that has a potential reservoir of bioactive compounds. Moreover, the structures of these compounds could serve as scaffold for the development of new pesticides.
dc.identifierAnais da Academia Brasileira de Ciências, v. 97, n. 3, p.e20241059, 2025.
dc.identifier1678-2690
dc.identifierhttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1181976
dc.identifierhttps://doi.org/10.1590/0001-3765202520241059
dc.identifier.urihttp://hdl.handle.net/123456789/483111
dc.languageeng
dc.rightsopenAccess
dc.subjectEndophytic fungus
dc.subjectPiperaceae
dc.subjectPimenta
dc.subjectFungo Para Controle Biológico
dc.subjectFusarium
dc.subjectColletotrichum Fragariae
dc.subjectEndophytes
dc.subjectBiological control agents
dc.subjectAntifungal agents
dc.subjectMetabolites
dc.subjectPiper
dc.subjectMicrobial pesticides
dc.titlePhytotoxic and antifungal compounds for agriculture are interestingly produced by the endophytic fungus Fusarium sp. (Ascomycota) isolated from Piper sp. (Piperaceae).
dc.typeArtigo de periódico

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