Infection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function

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dc.creatorHouston, E.F.
dc.creatorTaracha, E.L.N.
dc.creatorBrackenbury, L.
dc.creatorMacHugh, Niall D.
dc.creatorMcKeever, Declan J.
dc.creatorCharleston, B.
dc.creatorMorrison, W. Ivan
dc.date2008-12
dc.date2013-05-06T07:01:25Z
dc.date2013-05-06T07:01:25Z
dc.date.accessioned2026-06-27T17:12:34Z
dc.descriptionTheileria parva causes an acute lympho-proliferative disease in cattle, which can result in death of susceptible animals within 2-3 weeks of infection. Analyses of the cellular response in the lymph node draining the site of infection demonstrated an early T cell response, with the appearance of large numbers of uninfected lymphoblasts between 6 and 9 days p.i., coinciding with initial detection of parasitised cells. There was a marked increase in the representation of CD8+ T cells and the emergence of a sizable sub-population of CD2- CD8+ /ß T cells during this period. Analysis of T cell receptor ß chain variable (TCR BV) gene expression did not reveal any evidence for the involvement of a superantigen in stimulating the response. Responding lymph node cells were found to produce increased quantities of IFN and IL-10, and both the CD2+ CD8+ and CD2- CD8+ populations expressed IFN transcripts. Purified CD2+ CD8+ cells proliferated when stimulated in vitro with autologous parasitised cells or non-specific mitogens, whereas CD2- CD8+ cells were refractory to these stimuli. In contrast to the parasite-specific cytotoxic activity associated with T cell responses in immune cattle, the responses to primary infection exhibited variable levels of non-specific cytotoxic activity. Stimulation of purified CD2+ CD8+ T cells in vitro with autologous parasitised cells also failed to reveal evidence of specific cytotoxic activity. These findings indicate that primary infection with T. parva induces an aberrant T cell response that lacks appropriate effector activity.
dc.identifierhttps://hdl.handle.net/10568/28788
dc.identifier.urihttp://hdl.handle.net/123456789/145469
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceInternational Journal for Parasitology;38(14): 1693-1704
dc.subjecttheileria parva
dc.subjectcattle
dc.subjectinfection
dc.subjectlymphocytes
dc.subjectpathogenesis
dc.subjecttoxicity
dc.subjectcytokines
dc.titleInfection of cattle with Theileria parva induces an early CD8 T cell response lacking appropriate effector function
dc.typeJournal Article

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