Serum metabolomics identifies metabolic changes in obese cats fed enzymatically hydrolyzed poultry byproduct meal.
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Abstract Background: Obesity in cats is a complex metabolic condition, and understanding its metabolic processes is e ssential for gaining new insights into nutrition. Hypothesis/Objectives: Investigate the effects of enzymatically-hydrolyzed poultry byproduct meal (EHPM-c) on the serum metabolomic p rofile of obese cats. Animals: Eighteen adult, neutered, obese domestic cats were enrolled in the study. All subjects underwent comprehensive veterinary evaluations to confirm overall health and rule o ut concurrent systemic diseases, ensuring a homogenous study population. Methods:Cats were randomized into 2 groups and fed for 45 days with isonutritive diets containing either 30.8% conventional poultry byproduct meal (CPM-c) with 0.0% EHPM-c, or 17.0% CPM-c with 12.0% EHPM-c. After a 30-day diet standardization period, evaluationswereperformedatbaseline(T0)and45days(T45)afterconsumptionoftheexperimentaldiets.Metabolic spectra wereobtained using nuclearmagnetic resonance spectroscopy and analyzed using MetaboAnalyst®. Results: Principal component analysis did not identify differences in the overall metabolite profiles between the groups, but discriminant analysis identified changes in the intensities of valine, acetate, 1-methylhistidine, and glycerol in the test group after 45 days. Additionally, pathway analysis indicated a significant effect on propanoate metabolism, ethanol degradation, fatty acid biosynthesis, and glycerolipid metabolism in the test group. Conclusions and clinical importance: These findings suggest enhanced fat mobilization and improved utilization of branched chain amino acids, potentially benefiting ener gy metabolism in obese cats.
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Nuclearmagnetic resonance spectroscopy, Complex metabolic condition