Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility

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dc.creatorXu, Ming-Min
dc.creatorGu, Li-Hong
dc.creatorLv, Wan-Yue
dc.creatorDuan, Sheng-Chang
dc.creatorLi, Lian-Wei
dc.creatorDu, Yuan
dc.creatorLu, Li-Zhi
dc.creatorZeng, Tao
dc.creatorHou, Zhuo-Cheng
dc.creatorMa, Zhanshan Sam
dc.creatorChen, Wei
dc.creatorAdeola, A.C.
dc.creatorHan Jianlin
dc.creatorXu, Tie-Shan
dc.creatorDong, Yang
dc.creatorZhang, Ya-Ping
dc.creatorPeng, Min-Sheng
dc.date2022-11
dc.date2022-11-12T17:07:06Z
dc.date2022-11-12T17:07:06Z
dc.date.accessioned2026-06-27T17:03:25Z
dc.descriptionThe Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid β-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver.
dc.identifierhttps://hdl.handle.net/10568/125431
dc.identifier.urihttp://hdl.handle.net/123456789/140950
dc.languageen
dc.publisherElsevier
dc.rightsOpen Access
dc.sourceXu, Ming-Min, Gu, Li-Hong, Lv, Wan-Yue, Duan, Sheng-Chang, Li, Lian-Wei, Du, Yuan, Lu, Li-Zhi, Zeng, Tao, Hou, Zhuo-Cheng, Ma, Zhanshan Sam, Chen, Wei, Adeola, A.C., Jian-Lin, Han, Xu, Tie-Shan, Dong, Yang, Zhang, Ya-Ping and Peng, Min-Sheng. 2022. Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility. Genomics 114(6):110518.
dc.subjectgenetics
dc.subjectanimal breeding
dc.subjectduck breeds
dc.subjectfatty liver
dc.subjectmuscovy ducks
dc.titleChromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)