Evaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems

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dc.creatorBoulter, N.
dc.creatorBrown, D.
dc.creatorWilkie, G.
dc.creatorWilliamson, S.
dc.creatorKirvar, E.
dc.creatorKnight, P.
dc.creatorGlass, E.
dc.creatorCampbell, J.
dc.creatorMorzaria, S.P.
dc.creatorNene, Vishvanath M.
dc.creatorMusoke, A.J.
dc.creatorOliveria, C. de
dc.creatorGubbels, M.J.
dc.creatorJongejan, F.
dc.creatorHall, R.
dc.date1999-09
dc.date2013-06-11T09:24:55Z
dc.date2013-06-11T09:24:55Z
dc.date.accessioned2026-06-27T16:47:23Z
dc.descriptionThe major sporozoite surface antigen of Theileria annulata (SPAG-1) is a candidate for inclusion in a subunit vaccine. In this paper we summarize the results of 4 vaccination experiments using recombinant SPAG-1 expressed in different systems and presented in different adjuvants. The antigen has been presented as either a C terminal 108 amino acid peptide (called SR1) expressed as both beta-galactosidase and hepatitis B core antigen fusions or as a full-length form expressed as a GST fusion with an N terminal His6 tag. Different adjuvants, namely Freund's, saponin, ISCOMs and a proprietary adjuvant supplied by SmithKline Beecham were used, which are called SKBA. The data point to the conclusion that SPAG-1 can elicit partial protection and is therefore suitable for inclusion in an eventual multicomponent subunit vaccine.
dc.identifierhttps://hdl.handle.net/10568/29793
dc.identifier.urihttp://hdl.handle.net/123456789/133198
dc.languageen
dc.publisherWiley
dc.rightsLimited Access
dc.sourceTropical Medicine & International Health;4(9): A71-A77
dc.subjecttheileria parva
dc.subjectvaccines
dc.subjectantigens
dc.subjectsporozoites
dc.subjectimmunization
dc.subjectcalves
dc.titleEvaluation of recombinant sporozoite antigen SPAG-1 as a vaccine candidate against Theileria annulata by the use of different delivery systems
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)