The role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei

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dc.creatorYoung, J.R.
dc.creatorTurner, M.J.
dc.creatorWilliams, R.O.
dc.date1984
dc.date2013-05-06T07:01:39Z
dc.date2013-05-06T07:01:39Z
dc.date.accessioned2026-06-27T16:52:34Z
dc.descriptionThe variable surface glycoprotein (VSG) genes of Trypanosoma brucei have been classified into two groups depending upon whether or not duplication of the genes is observed when they are expressed. We report here the observation of duplication apparently linked to espression of the ILTaT 1.3 gene in the ETaR 1 trypanosome stock. In the ILTaR 1 stock, expression of the ILTaT 1.3 VSG did not involve a new duplication, but instead activation of a preexisting gene copy that had been apparently generated earlier by a duplication event analogous to that directly observed in the ETaR 1 trypanosomes. The results suggest that the well‐characterised gene duplications found with other VSG genes are common to all VSG genes but are not directly responsible for controlling expression. All currently available data can be accomodated by a model that assumes that gene duplication and replacement occurs independently of antigenic switching.
dc.identifierhttps://hdl.handle.net/10568/28884
dc.identifier.urihttp://hdl.handle.net/123456789/135799
dc.languageen
dc.publisherWiley
dc.rightsLimited Access
dc.sourceJournal of Cellular Biochemistry;24: 287-295
dc.subjecttrypanosoma brucei
dc.subjectglycoproteins
dc.titleThe role of duplication in the expression of a variable surface glycoprotein of Trypanosoma brucei
dc.typeJournal Article

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