Cross-resistance associated with development resistance to isometamidium in a clone of Trypanosoma congolense

No hay miniatura disponible

Fecha

Autores

Título de la revista

ISSN de la revista

Título del volumen

Editor

Resumen

Descripción

Resistance to isometamidium was increased 94-fold in a clone of Trypanosoma congolense (clone IL 1180) by repeated subcurative treatment of infected mice for 11 months. This was associated with 3.4-, 33-, and 4.2-fold increases in resistance to diminazene, homidium, and quinapyramine, respectively. Both T. congolense IL 1180 and the resistant derivative were able to undergo cyclical development in Glossina morsitans centralis tsetse flies, producing hypopharyngeal infection rates of 40.0 and 39.8 percent, respectively.

Palabras clave

trypanosoma congolense, drugs, resistance to chemicals

Citación

URI

http://hdl.handle.net/123456789/146748

Ver documento

https://hdl.handle.net/10568/30084

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)