Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL

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dc.creatorDixit, Shalabh
dc.creatorKumar Biswal, Akshaya
dc.creatorMin, Aye
dc.creatorHenry, Amelia
dc.creatorOane, Rowena H.
dc.creatorRaorane, Manish L.
dc.creatorLongkumer, Toshisangba
dc.creatorPabuayon, Isaiah M.
dc.creatorMutte, Sumanth K.
dc.creatorVardarajan, Adithi R.
dc.creatorMiro, Berta
dc.creatorGovindan, Ganesan
dc.creatorAlbano-Enriquez, Blesilda
dc.creatorPueffeld, Mandy
dc.creatorSreenivasulu, Nese
dc.creatorSlamet-Loedin, Inez
dc.creatorSundarvelpandian, Kalaipandian
dc.creatorTsai, Yuan-Ching
dc.creatorRaghuvanshi, Saurabh
dc.creatorHsing, Yue-Ie C.
dc.creatorKumar, Arvind
dc.creatorKohli, Ajay
dc.date2015-10-28
dc.date2024-12-19T12:55:01Z
dc.date2024-12-19T12:55:01Z
dc.date.accessioned2026-06-27T04:10:51Z
dc.descriptionSub-QTLs and multiple intra-QTL genes are hypothesized to underpin large-effect QTLs. Known QTLs over gene families, biosynthetic pathways or certain traits represent functional gene-clusters of genes of the same gene ontology (GO). Gene-clusters containing genes of different GO have not been elaborated, except in silico as coexpressed genes within QTLs. Here we demonstrate the requirement of multiple intra-QTL genes for the full impact of QTL qDTY12.1 on rice yield under drought. Multiple evidences are presented for the need of the transcription factor ‘no apical meristem’ (OsNAM12.1) and its co-localized target genes of separate GO categories for qDTY12.1 function, raising a regulon-like model of genetic architecture. The molecular underpinnings of qDTY12.1 support its effectiveness in further improving a drought tolerant genotype and for its validity in multiple genotypes/ecosystems/environments. Resolving the combinatorial value of OsNAM12.1 with individual intra-QTL genes notwithstanding, identification and analyses of qDTY12.1has fast-tracked rice improvement towards food security.
dc.identifierhttps://hdl.handle.net/10568/165377
dc.identifier.urihttp://hdl.handle.net/123456789/24172
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceDixit, Shalabh; Kumar Biswal, Akshaya; Min, Aye; Henry, Amelia; Oane, Rowena H.; Raorane, Manish L.; Longkumer, Toshisangba; Pabuayon, Isaiah M.; Mutte, Sumanth K.; Vardarajan, Adithi R.; Miro, Berta; Govindan, Ganesan; Albano-Enriquez, Blesilda; Pueffeld, Mandy; Sreenivasulu, Nese; Slamet-Loedin, Inez; Sundarvelpandian, Kalaipandian; Tsai, Yuan-Ching; Raghuvanshi, Saurabh; Hsing, Yue-Ie C.; Kumar, Arvind and Kohli, Ajay. 2015. Action of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL. Sci Rep, Volume 5, no. 1
dc.subjectbreeding methods
dc.subjectdrought tolerance
dc.subjectfood security
dc.subjectgenotypes
dc.subjectplant breeding
dc.subjectquantitative trait loci
dc.subjecttranscription factors
dc.subjectyields
dc.titleAction of multiple intra-QTL genes concerted around a co-localized transcription factor underpins a large effect QTL
dc.typeJournal Article

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Instituto Internacional de Investigación del Arroz (IRRI)