A multi-omics and human biomonitoring approach to assessing the effectiveness of fortified balanced energy–protein supplementation on maternal and newborn health in Burkina Faso: A study protocol

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dc.creatorBastos-Moreira, Yuri
dc.creatorOuédraogo, Lionel
dc.creatorBoevre, Marthe de
dc.creatorArgaw, Alemayehu
dc.creatorKok, Brenda de
dc.creatorHanley-Cook, Giles T.
dc.creatorDeng, Lishi
dc.creatorOuédraogo, Moctar
dc.creatorCompaoré, Anderson
dc.creatorTesfamariam, Kokeb
dc.creatorGanaba, Rasmané
dc.creatorHuybregts, Lieven
dc.creatorToe, Laeticia Celine
dc.creatorLachat, Carl
dc.creatorKolsteren, Patrick
dc.creatorSaeger, Sarah de
dc.creatorDailey-Chwalibóg, Trenton
dc.date2023-09-19
dc.date2023-10-11T19:31:14Z
dc.date2023-10-11T19:31:14Z
dc.date.accessioned2026-06-27T15:34:30Z
dc.descriptionFortified balanced energy–protein (BEP) supplementation is a promising intervention for improving maternal health, birth outcomes and infant growth in low- and middle-income countries. This nested biospecimen sub-study aimed to evaluate the physiological effect of multi-micronutrient-fortified BEP supplementation on pregnant and lactating women and their infants. Pregnant women (15–40 years) received either fortified BEP and iron–folic acid (IFA) (intervention) or IFA only (control) throughout pregnancy. The same women were concurrently randomized to receive either a fortified BEP supplement during the first 6 months postpartum in combination with IFA for the first 6 weeks (i.e., intervention) or the postnatal standard of care, which comprised IFA alone for 6 weeks postpartum (i.e., control). Biological specimens were collected at different timepoints. Multi-omics profiles will be characterized to assess the mediating effect of BEP supplementation on the different trial arms and its effect on maternal health, as well as birth and infant growth outcomes. The mediating effect of the exposome in the relationship between BEP supplementation and maternal health, birth outcomes and infant growth were characterized via biomonitoring markers of air pollution, mycotoxins and environmental contaminants. The results will provide holistic insight into the granular physiological effects of prenatal and postnatal BEP supplementation.
dc.identifierhttps://hdl.handle.net/10568/132205
dc.identifier.urihttp://hdl.handle.net/123456789/108271
dc.languageen
dc.publisherMDPI
dc.rightsOpen Access
dc.sourceBastos-Moreira, Yuri; Ouédraogo, Lionel; De Boevre, Marthe; Argaw, Alemayehu; de Kok, Brenda; Hanley-Cook, Giles T.; Huybregts, Lieven; et al. 2023. A multi-omics and human biomonitoring approach to assessing the effectiveness of fortified balanced energy–protein supplementation on maternal and newborn health in Burkina Faso: A study protocol. Nutrients 15(18): 4056. https://doi.org/10.3390/nu15184056
dc.subjectmaternal and child health
dc.subjectinfants
dc.subjectnutrition
dc.subjectparturition
dc.subjectperinatal period
dc.subjectpregnant women
dc.subjectprotein content
dc.titleA multi-omics and human biomonitoring approach to assessing the effectiveness of fortified balanced energy–protein supplementation on maternal and newborn health in Burkina Faso: A study protocol
dc.typeJournal Article

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Instituto Internacional de Investigación sobre Políticas Alimentarias (IFPRI)