Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

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dc.creatorLi, X.
dc.creatorYang, J.
dc.creatorShen, M.
dc.creatorXie, X-L.
dc.creatorLiu, G-J.
dc.creatorXu, Y-X.
dc.creatorLv, F-H.
dc.creatorYang, H.
dc.creatorYang, Y-L.
dc.creatorLiu, C-B.
dc.creatorZhou, P.
dc.creatorWan, P-C.
dc.creatorZhang, Y-S.
dc.creatorGao, L.
dc.creatorYang, J-Q.
dc.creatorPi, W-H.
dc.creatorRen, Y-L.
dc.creatorShen, Z-Q.
dc.creatorWang, F.
dc.creatorDeng, J.
dc.creatorXu, S.S.
dc.creatorSalehian-Dehkordi, H.
dc.creatorHehua, E.
dc.creatorEsmailizadeh, A.
dc.creatorDehghani-Qanatqestani, M.
dc.creatorŠtěpánek, O.
dc.creatorWeimann, C.
dc.creatorErhardt, G.
dc.creatorAmane, A.
dc.creatorMwacharo, Joram M.
dc.creatorHan Jianlin
dc.creatorHanotte, Olivier H.
dc.creatorLenstra, J.A.
dc.creatorKantanen, J.
dc.creatorColtman, D.W.
dc.creatorKijas, J.W.
dc.creatorBruford, M.W.
dc.creatorPeriasamy, K.
dc.creatorWang, X-H.
dc.creatorLi, M-H.
dc.date2020-06-04
dc.date2020-12-27T14:25:15Z
dc.date2020-12-27T14:25:15Z
dc.date.accessioned2026-06-27T16:35:58Z
dc.descriptionUnderstanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals.
dc.identifierhttps://hdl.handle.net/10568/110647
dc.identifier.urihttp://hdl.handle.net/123456789/127723
dc.languageen
dc.publisherSpringer
dc.rightsOpen Access
dc.sourceLi, X., Yang, J., Shen, M., Xie, X-L., Liu, G-J., Xu, Y-X., Lv, F-H., Yang, H., Yang, Y-L., Liu, C-B., Zhou, P., Wan, P-C., Zhang, Y-S., Gao, L., Yang, J-Q., Pi, W-H., Ren, Y-L., Shen, Z-Q., Wang, F., Deng, J., Xu, S.S., Salehian-Dehkordi, H., Hehua, E., Esmailizadeh, A., Dehghani-Qanatqestani, M., Štěpánek, O., Weimann, C., Erhardt, G., Amane, A., Mwacharo, Joram M., Jianlin, Han, Hanotte, O.H., Lenstra, J.A., Kantanen, J., Coltman, D.W., Kijas, J.W., Bruford, M.W., Periasamy, K., Wang, X-H. and Li, M-H. 2020. Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nature Communications 11:2815.
dc.subjectgenomics
dc.subjectgenetics
dc.subjectsheep
dc.subjectagronomic characters
dc.subjectanimal health
dc.subjectsmall ruminants
dc.titleWhole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits
dc.typeJournal Article

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Instituto Internacional de Investigaciones Pecuarias (ILRI)