Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa

Vista sencilla de ítem
dc.creatorDewals, B.
dc.creatorGillet, L.
dc.creatorGerdes, T.
dc.creatorTaracha, E.L.N.
dc.creatorThiry, E.
dc.creatorVanderplasschen, A.
dc.date2005-10-31
dc.date2013-06-11T09:25:14Z
dc.date2013-06-11T09:25:14Z
dc.date.accessioned2026-06-27T16:35:32Z
dc.descriptionBovine herpesvirus 4 (BoHV-4) has been isolated from cattle throughout the world. Interestingly, a survey of wild African buffaloes mainly from the Maasai Mara Game Reserve in Kenya revealed that 94% of the animals tested had anti-BoHV-4 antibodies [Rossiter, P.B., Gumm, I.D., Stagg, D.A., Conrad, P.A., Mukolwe, S., Davies, F.G., White, H., 1989. Isolation of bovine herpesvirus-3 from African buffaloes (Syncerus caffer). Res. Vet. Sci. 46, 337–343]. These authors also proposed that the serological antigenic relationship existing between BoHV-4 and alcelaphine herpesvirus 1 (AlHV-1) could confer to BoHV-4 infected buffaloes a protective immune response against lethal AlHV-1 infection. In the present study, we addressed two questions related to Rossiter et al. paper. Firstly, to investigate the role of the African buffalo as a natural host species of BoHV-4, the seroprevalence of anti-BoHV-4 antibodies was analysed in wild African buffaloes throughout eastern and southern Africa. A total of 400 sera was analysed using two complementary immunofluorescent assays. These analyses revealed that independently of their geographical origin, wild African buffaloes exhibit a seroprevalence of anti-BoHV-4 antibodies higher than 68%. This result is by far above the seroprevalence generally observed in cattle. Our data are discussed in the light of our recent phylogenetic study demonstrating that the BoHV-4 Bo17 gene has been acquired from a recent ancestor of the African buffalo. Secondly, we investigated the humoral antigenic relationship existing between BoHV-4 and AlHV-1. Our results demonstrate that among the antigens expressed in AlHV-1 infected cells, epitope(s) recognised by anti-BoHV-4 antibodies are exclusively nuclear, suggesting that the putative property of BoHV-4 to confer an immune protection against AlHV-1 relies on a cellular rather than on a humoral immune response.
dc.identifierhttps://hdl.handle.net/10568/29872
dc.identifier.urihttp://hdl.handle.net/123456789/127495
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceVeterinary Microbiology;110 (3-4): 209-220
dc.subjectafrican buffaloes
dc.subjectwild animals
dc.subjectantibodies
dc.subjectbovine herpesvirus
dc.subjectdisease prevalence
dc.subjectmicrobiology
dc.titleAntibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)