Identification of mechanisms of natural resistance to African trypanosomiasis in cattle

Vista sencilla de ítem
dc.creatorNaessens, Jan
dc.creatorTeale, A.J.
dc.creatorSileghem, M.R.
dc.date2002-09-10
dc.date2010-05-17T06:49:38Z
dc.date2010-05-17T06:49:38Z
dc.date.accessioned2026-06-27T17:13:26Z
dc.descriptionNatural resistance to African trypanosomiasis in certain Bos taurus cattle in West Africa, called trypanotolerance, may hold solutions for control of this economically crippling disease. Comparison of immune responses between trypanotolerant and trypanosusceptible cattle have shown some differences in antibody response, complement level and cytokine expression, but it is not known whether these differences are the cause of resistance. Two experiments were carried out to assess the contribution of the immune and haemopoietic systems to trypanotolerance. The production of haemopoietic chimaeras from trypanotolerant and susceptible twin calves and comparison of their responses after infection with singleton calves, allowed an assessment of the role of the haemopoietic system in trypanotolerance. An in vivo depletion of CD4 cells in the two breeds allowed an appraisal of the role of T and B lymphocytes in trypanotolerance. The results of the two experiments suggest that natural resistance comprises at least two mechanisms, an innate mechanism that controls parasite growth, and another, involving the haemopoietic system, that is able to limit anaemia. This supports the hypothesis that innate mechanisms in trypanotolerant cattle are more efficient in controlling disease, making them less reliant on antibody responses.
dc.identifierhttps://hdl.handle.net/10568/1537
dc.identifier.urihttp://hdl.handle.net/123456789/145896
dc.languageen
dc.publisherElsevier
dc.rightsLimited Access
dc.sourceNaessens, J., Teale, A. J., & Sileghem, M. (2002). Identification of mechanisms of natural resistance to African trypanosomiasis in cattle. In Veterinary Immunology and Immunopathology (Vol. 87, Issues 3–4, pp. 187–194). Elsevier BV. https://doi.org/10.1016/s0165-2427(02)00070-3
dc.subjecttrypanosomiasis
dc.subjectdisease control
dc.subjectcattle
dc.subjectantibodies
dc.subjectb lymphocytes
dc.subjectcytokines
dc.subjectdisease resistance
dc.subjecthaematopoiesis
dc.subjectimmune response
dc.subjectt lymphocytes
dc.titleIdentification of mechanisms of natural resistance to African trypanosomiasis in cattle
dc.typeJournal Article

Archivos

Colecciones

Instituto Internacional de Investigaciones Pecuarias (ILRI)